2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. LXR Stearoyl-CoA Desaturase (SCD) Fatty Acid Synthase (FASN)
  4. PFM046

PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC50 of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models.

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PFM046 Chemical Structure

PFM046 Chemical Structure

CAS No. : 3053859-57-4

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PFM046 Related Antibodies

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Description

PFM046 is the antagonist for liver X receptor (LXR), that inhibits the activation of LXRα and LXRβ with IC50 of 2.04 μM and 1.58 μM. PFM046 inhibits the expression of SCD1 and FASN, upregulates the expression of ABCA1, and exhibits antitumor efficacy in mouse models[1].

IC50 & Target

IC50: 2.04 μM (LXRα); 1.58 μM (>LXRβ)
Molecular Weight

422.64

Formula

C29H42O2
CAS No.
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@H](C)[C@H](CC3=CC=CC=C3)O)([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PFM046 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PFM0463053859-57-4PFM 046PFM-046LXRStearoyl-CoA Desaturase (SCD)Fatty Acid Synthase (FASN)Liver X receptorB16F1LLCC57BL/6 mouseInhibitorinhibitorinhibit

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