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LasR antagonist

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158124
    LasR antagonist 1

    		Bacterial Infection
    LasR antagonist 1 (Compound 7) is an antagonist for LasR with an IC50 of 0.4 μM, that modulates the quorum sensing (QS) in the opportunistic pathogen Pseudomonas aeruginosa .
    LasR antagonist 1
  • HY-162957
    LasR-IN-5

    		Others Infection
    LasR-IN-5 (compound 3C) is a LasR antagonist with an IC50 of 1.37 μM, demonstrating a 77% inhibition of biofilm formation in Pseudomonas aeruginosa. LasR-IN-5 also exhibits quorum sensing (QS) inhibition activity and has potential applications in Pseudomonas aeruginosa infection research .
    LasR-IN-5
  • HY-122143
    V-06-018

    		Bacterial Infection
    V-06-018 is a potent LasR antagonist with an IC50 value of 5.2 µM. V-06-018 can be used as chemical probes of quorum sensing (QS) in Pseudomonas aeruginosa .
    V-06-018
  • HY-131337
    RhlR antagonist 1

    		Bacterial Infection
    RhlR antagonist 1 is a potent RhlR antagonist with an IC50 of 26 μM. RhlR antagonist 1 displays selective RhlR antagonism over LasR and PqsR, strong inhibition of biofilm formation in static and dynamic settings, and reduces production of virulence factors such as rhamnolipid and pyocyanin in P. aeruginosa. RhlR antagonist 1 can be utilized for developing QS-modulating molecules in the control of P. aeruginosa infections . RhlR antagonist 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    RhlR antagonist 1

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