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M. abscessus

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136278
    DETA NONOate
    4 Publications Verification

    Diethylamine NONOate; NOC-18

    		 NO Synthase Cardiovascular Disease
    DETA NONOate (NOC 18) is an exogenous nitric oxide (NO) donor. DETA NONOate shows a slow release normal amounts of NO and long-acting .
    DETA NONOate
  • HY-143484
    844-TFM

    		Bacterial Infection
    844-TFM is a NBTI (novel bacterial topoisomerase inhibitor) DNA gyrase inhibitor, with an IC50 of 1.5 μM. 844-TFM exhibits bactericidal properties against M. abscessus .
    844-TFM
  • HY-170519
    K13787

    		Bacterial Infection
    K13787 is an acetohydroxyacid synthase (AHAS) inhibitor with antibacterial activity. K13787 has antibacterial activity against a variety of nontuberculous mycobacteria (NTM) and clarithromycin (CLR) resistant strains .
    K13787
  • HY-149064
    Antituberculosis agent-9

    		Bacterial Infection
    Antituberculosis agent-9 (Compound 5a) is an orally active antitubercular agent with an MIC of 0.5 μg/mL against H37Ra .
    Antituberculosis agent-9
  • HY-159899
    DHFR-IN-22

    		Bacterial Antibiotic Dihydrofolate reductase (DHFR)
    DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC50 of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC50 of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC50 of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections .
    DHFR-IN-22
  • HY-163181
    MSU-43085

    		Bacterial Infection
    MSU-43085 is an orally active MmpL3 inhibitor of Mycobacterium tuberculosis (Mtb). MSU-43085 effectively inhibits Mtb in an acute murine tuberculosis infection model. MSU-43085 can be used in tuberculosis research .
    MSU-43085
  • HY-161802
    Antibacterial agent 228

    		Bacterial Infection
    Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC50 for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessus ATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .
    Antibacterial agent 228
  • HY-161890
    Antimycobacterial agent-8

    		DNA/RNA Synthesis Bacterial Infection
    Antimycobacterial agent-8 (Compound 49) is an inhibitor for DNA gyrase. Antimycobacterial agent-8 exhibits antibacterial activity against Mycobacterium tuberculosis and M. abscessus with MIC90 of 2.5 μM and 0.63 μM. Antimycobacterial agent-8 exhibits good plasma protein binding ability in mice .
    Antimycobacterial agent-8
  • HY-143483
    NBTIs-IN-5

    		Bacterial Infection
    NBTIs-IN-5 (Compound 5r) is a NBTI (Novel Bacterial Topoisomerase Inhibitor) DNA gyrase inhibitor with an IC50 of 1.5 μM against Mycobacterium abscessus (Mabs) DNA gyrase. NBTIs-IN-5 inhibits Mabs bamboo bacterial growth with an MIC90 of 0.4 μM .
    NBTIs-IN-5

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