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MZ-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107425
    MZ 1
    15+ Cited Publications

    		 PROTACs Epigenetic Reader Domain Cancer
    MZ 1 is a PROTAC connected by ligands for von Hippel-Lindau and BRD4. MZ 1 potently and rapidly induces reversible, long-lasting, and selective removal of BRD4 over BRD2 and BRD3. Kds of 382/120, 119/115, and 307/228 nM for BRD4 BD1/2, BRD3 BD1/2, and BRD2 BD1/2, respectively [1].
    MZ 1
  • HY-107425B
    cis-MZ 1 hydrate

    		Epigenetic Reader Domain Cancer
    cis-MZ 1 hydrate is a negative control for BRD4-targeted PROTAC MZ 1 (HY-107425). cis-MZ 1 or MZ 1 is a combination of the von Hippel-Lindau ligand (red part in the structural formula) and the BRD4 ligand (blue part in the structural formula). The Kd of MZ 1 for BRD4 BD1/2 was 382 nM and 120 nM, respectively [1].
    cis-MZ 1 hydrate
  • HY-107425A
    cis-MZ 1

    		PROTACs Epigenetic Reader Domain Cancer
    cis-MZ 1 is a negative control of MZ 1 (HY-107425). cis-MZ 1 is a PROTAC targeting to BRD4 [1].
    cis-MZ 1
  • HY-155370
    IR808-TZ

    		PROTACs Cancer
    IR808-TZ is a Tetraazine base station shipped with. IR808-TZ is a biocompatible PROTAC (BT-PROTAC) that can activate MZ1 and reduce BRD4 specificity [1].
    IR808-TZ

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