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Mycobacterium avium

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (3) Bacterial (13) Biochemical Assay Reagents (6) Dihydrofolate reductase (DHFR) (1) Glucocorticoid Receptor (1)
By Research Areas:	Infection (12) Inflammation/Immunology (2) Metabolic Disease (1)

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Biochemical Assay Reagents

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113784

Thiocarlide Isoxyl	Antibiotic Bacterial	Infection
Thiocarlide is a potent antibacterial agent. Thiocarlide inhibits Mycobacterium tuberculosis H37Rv, Mycobacterium bovisBCG, Mycobacterium avium, and Mycobacterium aurum A+ with MICs of 2.5, 0.5, 2.0 and 2.0 μg/mL, respectively .

HY-D1005A19

Poloxamer 333 (P103) PEG-PPG-PEG, 4950 (Averag)	Biochemical Assay Reagents Bacterial	Infection
Poloxamer 333 P103 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4950. Poloxamer 333 P103 exhibits antimicrobial activity, that inihibits 90% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 333 P103 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A4

Poloxamer 122 (L42) PEG-PPG-PEG, 1630 (Averag)	Biochemical Assay Reagents Bacterial	Infection
Poloxamer 122 L42 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1630. Poloxamer 122 L42 exhibits antimicrobial activity, that inihibits 56% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 122 L42 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A8

Poloxamer 181 (L61) PEG-PPG-PEG, 2000 (Averag)	Biochemical Assay Reagents Bacterial	Infection
Poloxamer 181 L61 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2000. Poloxamer 181 L61 exhibits antimicrobial activity, that inihibits 91% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 181 L61 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A9

Poloxamer 183 (L63) PEG-PPG-PEG, 2650 (Averag)	Biochemical Assay Reagents Bacterial	Infection
Poloxamer 183 L63 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2650. Poloxamer 183 L63 exhibits antimicrobial activity, that inihibits 83% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 183 L63 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A21

Poloxamer 335 (P105) PEG-PPG-PEG, 6500 (Averag)	Biochemical Assay Reagents Bacterial	Infection
Poloxamer 335 P105 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6500. Poloxamer 335 P105 exhibits antimicrobial activity, that inihibits 86% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 334 P104 exhibits muscular toxicity. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A10

Poloxamer 184 (L64) PEG-PPG-PEG, 2900 (Averag)	Biochemical Assay Reagents Bacterial	Infection Inflammation/Immunology
Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-135285

Rifamexil	Antibiotic Bacterial	Infection
Rifamexil is an antibiotic Rifamycin (HY-B1907A) derivative that is active against Mycobacterium avium complex and other mycobacteria .

HY-113729

B 746	Bacterial	Infection
B746 is a clofazimine analog with anti-Mycobacterium avium complex (MAC) activity and is less effective when used with clofazimine or streptomycin .

HY-19814

Toripristone RU-40555	Glucocorticoid Receptor	Infection Inflammation/Immunology
Toripristone (RU-40555) is a cortisol receptor inhibitor. Toripristone combined with clarithromycin can increase the antibacterial activity of Mycobacterium avium complex infection .

HY-113834

(R,R)-Ethambutol	Bacterial	Infection
(R,R)-Ethambutol is an antituberculosis compound with tuberculosis inhibitory activity. (R,R)-Ethambutol is often used in combination with other antituberculosis compounds to enhance the efficacy. (R,R)-Ethambutol can also be used to inhibit Mycobacterium avium complex infection and Mycobacterium kansasii infection .

HY-N12823

Caprazene	Bacterial	Metabolic Disease
Caprazene is an antimycobacterial compound and precursor molecule for semi-synthetic antibacterial antibiotics, used for studies on tuberculosis and Mycobacterium avium complex infections, which can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture .

HY-N1673

2,5-Dihydroxybenzaldehyde Gentisaldehyde	Bacterial	Infection
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against *S. aureus* strains with a MIC₅₀ of 500 mg/L .

HY-159899

DHFR-IN-22	Bacterial Antibiotic Dihydrofolate reductase (DHFR)
DHFR-IN-22 (Compound 8) is a DHFR (Dihydrofolate Reductase) inhibitor belonging to the class of 2,4-diaminopyrimidine compounds. DHFR-IN-22 exhibits significant inhibitory activity against purified DHFR enzyme and major species of nontuberculous mycobacteria (NTM), namely Mycobacterium avium and Mycobacterium abscessus. It shows an IC₅₀ of 1.1 nM and MIC of 1.5 μg/mL against M. abscessus, and an IC₅₀ of 6.3 nM and MIC of 0.1 μg/mL against M. avium. Additionally, it demonstrates an IC₅₀ of 2100 nM against human DHFR. DHFR-IN-22 holds potential for studying novel strategies to combat NTM infections .

Cat. No.	Product Name	Type

HY-D1005A19

Poloxamer 333 (P103) PEG-PPG-PEG, 4950 (Averag)	Co-solvents
Poloxamer 333 P103 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4950. Poloxamer 333 P103 exhibits antimicrobial activity, that inihibits 90% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 333 P103 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 333 (P103)

PEG-PPG-PEG, 4950 (Averag)

Co-solvents

Poloxamer 333 P103 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 4950. Poloxamer 333 P103 exhibits antimicrobial activity, that inihibits 90% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 333 P103 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A4

Poloxamer 122 (L42) PEG-PPG-PEG, 1630 (Averag)	Co-solvents
Poloxamer 122 L42 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1630. Poloxamer 122 L42 exhibits antimicrobial activity, that inihibits 56% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 122 L42 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 122 (L42)

PEG-PPG-PEG, 1630 (Averag)

Co-solvents

Poloxamer 122 L42 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 1630. Poloxamer 122 L42 exhibits antimicrobial activity, that inihibits 56% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 122 L42 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A8

Poloxamer 181 (L61) PEG-PPG-PEG, 2000 (Averag)	Co-solvents
Poloxamer 181 L61 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2000. Poloxamer 181 L61 exhibits antimicrobial activity, that inihibits 91% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 181 L61 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 181 (L61)

PEG-PPG-PEG, 2000 (Averag)

Co-solvents

Poloxamer 181 L61 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2000. Poloxamer 181 L61 exhibits antimicrobial activity, that inihibits 91% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 181 L61 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A9

Poloxamer 183 (L63) PEG-PPG-PEG, 2650 (Averag)	Co-solvents
Poloxamer 183 L63 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2650. Poloxamer 183 L63 exhibits antimicrobial activity, that inihibits 83% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 183 L63 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 183 (L63)

PEG-PPG-PEG, 2650 (Averag)

Co-solvents

Poloxamer 183 L63 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2650. Poloxamer 183 L63 exhibits antimicrobial activity, that inihibits 83% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 183 L63 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A21

Poloxamer 335 (P105) PEG-PPG-PEG, 6500 (Averag)	Co-solvents
Poloxamer 335 P105 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6500. Poloxamer 335 P105 exhibits antimicrobial activity, that inihibits 86% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 334 P104 exhibits muscular toxicity. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 335 (P105)

PEG-PPG-PEG, 6500 (Averag)

Co-solvents

Poloxamer 335 P105 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 6500. Poloxamer 335 P105 exhibits antimicrobial activity, that inihibits 86% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 334 P104 exhibits muscular toxicity. Poloxamer 334 P104 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

HY-D1005A10

Poloxamer 184 (L64) PEG-PPG-PEG, 2900 (Averag)	Co-solvents
Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

Poloxamer 184 (L64)

PEG-PPG-PEG, 2900 (Averag)

Co-solvents

Poloxamer 184 L64 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 2900. Poloxamer 184 L64 exhibts short-term dermal toxicity characterized by slight erythema and intradermal inflammatory response. Poloxamer 184 L64 exhibits antimicrobial activity, that inihibits 60% Mycobacterium avium complex at concentration of 1 mg/mL. Poloxamer 184 L64 forms thermoreversible hydrogel, that is utilized in food additives, drug delivery carriers in cosmetics, pharmaceutical ingredients and tissue engineering .

2,5-Dihydroxybenzaldehyde Gentisaldehyde	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Polyphenols Disease Research Fields	Bacterial
2,5-Dihydroxybenzaldehyde (Gentisaldehyde) is a naturally occurring antimicrobial that inhibits the growth of Mycobacterium avium subsp. paratuberculosis. 2,5-Dihydroxybenzaldehyde is active against *S. aureus* strains with a MIC₅₀ of 500 mg/L .

Caprazene	Structural Classification Microorganisms Antibiotics Source classification	Bacterial
Caprazene is an antimycobacterial compound and precursor molecule for semi-synthetic antibacterial antibiotics, used for studies on tuberculosis and Mycobacterium avium complex infections, which can be isolated from the acid-treated caprazamycin (CPZ) A-G mixture .

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Mycobacterium avium

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Natural
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