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Results for "

Mycobacterium smegmatis

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13579
    BTZ043
    3 Publications Verification

    		 Bacterial Antibiotic Infection
    BTZ043 is an inhibitor of decaprenyl-phosphoribose-epimerase (DprE1), with MICs of of 2.3 nM and 9.2 nM for M. tuberculosis H37Rv and Mycobacterium smegmatis, respectively.
    BTZ043
  • HY-121463
    Rubrosulphin

    		Bacterial Infection
    Rubrosulphin is a fungal metabolite, which can be isolated from Aspergillus sp.. Rubrosulphin exhibits slight anti-tuberculosis activity, inhibits Mycobacterium bovis and M. smegmatis with MIC >200 µg/mL .
    Rubrosulphin
  • HY-161802
    Antibacterial agent 228

    		Bacterial Infection
    Antibacterial agent 228 (Compound 8) inhibits the mycobacterial ribosome (IC50 for Mycobacterium smegmatis is 2.31 μM) and exhibits antibacterial activity against M. tuberculosis H37Rv (MIC=2 and 0.25 μg/mL for wildtype and Δ1258c mutant), M. abscessus ATCC 19977 (MIC=8 and 8 μg/mL for wildtype and Δ2780c mutant) and M. smegmatis (MIC=8 μg/mL) .
    Antibacterial agent 228
  • HY-120733
    Calpinactam

    FKI-4905

    		 Bacterial Endogenous Metabolite Infection Inflammation/Immunology
    Calpinactam (FKI-4905), a fungal metabolite, is a new anti-mycobacterial agent.Calpinactam is active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibits the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 μg/ml, respectively .
    Calpinactam
  • HY-161148
    FtsZ-IN-9

    		Bacterial Infection
    FtsZ-IN-9 (compound 11) is an antimicrobial agent. FtsZ-IN-9 inhibits the assembly of Mycobacterium smegmatis FtsZ (MsFtsZ)[1].
    FtsZ-IN-9
  • HY-149998
    Antimycobacterial agent-5

    		Bacterial Reactive Oxygen Species Apoptosis Infection
    Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide targeting mycobacterial electron transport chain (ETC) airway CIII2CIV2 supercomplexes. The IC50 value of Antimycobacterial agent-5 against Mycobacterium smegmatisCIII2CIV2 is 441 nM .
    Antimycobacterial agent-5
  • HY-151548
    Mtb-cyt-bd oxidase-IN-1

    		Bacterial Infection
    Mtb-cyt-bd oxidase-IN-1 (compound 1x) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC50 value of 0.13 μM. Mtb-cyt-bd oxidase-IN-1 can be used in tuberculosis research .
    Mtb-cyt-bd oxidase-IN-1
  • HY-151550
    Mtb-cyt-bd oxidase-IN-3

    		Bacterial Infection
    Mtb-cyt-bd oxidase-IN-3 (compound 1u) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC50 value of 0.36 μM. Mtb-cyt-bd oxidase-IN-3 inhibits the growth of Mycobacterium tuberculosis (MIC=32 μM). Mtb-cyt-bd oxidase-IN-3 can be used in tuberculosis research .
    Mtb-cyt-bd oxidase-IN-3
  • HY-146489
    Anti-infective agent 3

    		Bacterial Parasite Infection
    Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .
    Anti-infective agent 3
  • HY-146488
    Anti-infective agent 2

    		Parasite Bacterial Infection
    Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .
    Anti-infective agent 2
  • HY-146487
    Anti-infective agent 1

    		Bacterial Parasite Infection
    Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC50 values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .
    Anti-infective agent 1
  • HY-151551
    Mtb-cyt-bd oxidase-IN-4

    		Bacterial Infection
    Mtb-cyt-bd oxidase-IN-4 (compound 1g) is a Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) inhibitor with an IC50 value of 0.25 μM. Mtb-cyt-bd oxidase-IN-4 inhibits the growth of Mycobacterium tuberculosis (MIC=8 μM). Mtb-cyt-bd oxidase-IN-4 can be used in tuberculosis research .
    Mtb-cyt-bd oxidase-IN-4
  • HY-151549
    Mtb-cyt-bd oxidase-IN-2

    		Bacterial Infection
    Mtb-cyt-bd oxidase-IN-2 is an inhibitor of Mycobacterium tuberculosis cytochrome bd oxidase (Mtb cyt-bd oxidase) with an IC50 value of 0.67 μM. Mtb-cyt-bd oxidase-IN-2 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 256 μM. Mtb-cyt-bd oxidase-IN-2 can be used for the research of infection .
    Mtb-cyt-bd oxidase-IN-2
  • HY-N2544
    Dehydroglaucine

    		Bacterial Infection
    Dehydroglaucine is a potent antimicrobial alkaloid .
    Dehydroglaucine
  • HY-129262
    Deoxypheganomycin D

    		Antibiotic Infection
    Deoxypheganomycin D is a specific antimycobacterial inhibitor with activity against the growth of Mycobacterium smegmatis ATCC 607. Deoxypheganomycin D inhibits bacterial growth in a bacteriostatic manner at concentrations up to 7 X 10(-5) M and has no cross-resistance to other antibiotics such as paromomycin, capreomycin, viomycin, streptothricin, kanamycin and streptomycin. Deoxypheganomycin D only partially inhibits the cell growth of M. 607 at 2.8 X 10(-7) M, but has no significant inhibitory effect on DNA, RNA or protein synthesis, while there is a significant reduction in the accumulation of [14C]glycerol-derived radioactive material in the cell wall. Deoxypheganomycin D affects the influx of the amino acid leucine in the presence of 7 X 10(-6) M, while having no effect on the influx of thymidine, whereas the reverse is true for the outflux. The effects of deoxypheganomycin D may be related to cell membrane and specific mycobacterial lipid components .
    Deoxypheganomycin D
  • HY-126735
    Saquayamycin D

    		Antibiotic Bacterial Infection
    Saquayamycin D is an antibiotic, which can be isolated from Streptomyces nodosus culture broth. Saquayamycin D exhibits antibacterial activity against various gram-positive bacteria with MIC of 12.5-50 μg/mL. Saquayamycin D inhibits the proliferation of Doxorubicin (HY-15142)-sensitive P388/S and Doxorubicin-resistant P388/ADR with IC50 of 0.15 and 0.15 μg/mL .
    Saquayamycin D

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