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Results for "

N-Desethyl Sunitinib

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10873
    N-Desethyl Sunitinib
    5+ Cited Publications

    SU-12662

    		 Drug Metabolite Cancer
    N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
    N-Desethyl Sunitinib
  • HY-10873S
    N-Desethyl Sunitinib-d5

    		Isotope-Labeled Compounds Drug Metabolite Cancer
    N-Desethyl Sunitinib-d5 is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
    N-Desethyl Sunitinib-d5
  • HY-138813
    N-Desethyl Sunitinib hydrochloride
    5+ Cited Publications

    SU-12662 hydrochloride

    		 Drug Metabolite Cancer
    N-Desethyl Sunitinib (SU-12662) (hydrochloride) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
    N-Desethyl Sunitinib hydrochloride
  • HY-10873S2
    N-Desethyl Sunitinib-d5 hydrochloride

    SU-12662-d5 hydrochloride

    		 Isotope-Labeled Compounds Drug Metabolite Cancer
    N-Desethyl Sunitinib-d5 (hydrochloride) is a deuterated labeled N-Desethyl Sunitinib . N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively .
    N-Desethyl Sunitinib-d5 hydrochloride
  • HY-10873S1
    N-Desethyl Sunitinib-d4 TFA

    SU-12662-d4 TFA

    		 Drug Metabolite Isotope-Labeled Compounds Cancer
    N-Desethyl Sunitinib-d4 (SU-12662-d4) TFA is deuterium-labeled N-Desethyl Sunitinib (HY-10873) .
    N-Desethyl Sunitinib-d4 TFA
  • HY-10873R
    N-Desethyl Sunitinib (Standard)

    		Drug Metabolite Cancer
    N-Desethyl Sunitinib (Standard)
  • HY-138813R
    N-Desethyl Sunitinib (hydrochloride) (Standard)

    		Drug Metabolite Cancer
    Glycochenodeoxycholic acid sodium salt (Standard) is the analytical standard of Glycochenodeoxycholic acid sodium salt. This product is intended for research and analytical applications. Glycochenodeoxycholic acid sodium salt (Sodium glycochenodeoxycholate) is a relatively toxic bile salt generated in the liver from chenodeoxycholic acid and glycine. Glycochenodeoxycholic acid sodium salt inhibits Autophagosome formation and impairs lysosomal function by inhibiting lysosomal proteolysis and increasing lysosomal pH in human normal liver cells, leading to the Apoptosis of human hepatocyte cells. Glycochenodeoxycholic acid sodium salt induces stemness and chemoresistance via activating STAT3 signaling pathway in hepatocellular carcinoma cells (HCC). Glycochenodeoxycholic acid sodium salt is promising for research in the field of cholestasis desease, hepatocellular carcinoma and primary sclerosing cholangitis (PSC) .
    N-Desethyl Sunitinib (hydrochloride) (Standard)

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