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NNK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Drug Derivative (1) Endogenous Metabolite (3) Isotope-Labeled Compounds (2) Reactive Oxygen Species (1)
By Research Areas:	Cancer (5)

7

Inhibitors & Agonists

3

Natural
Products

3

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*NNK* 1 Publications Verification	Endogenous Metabolite	Cancer
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

NNK-d4 4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone-d₄	Endogenous Metabolite	Others
NNK-d₄ is the deuterium labeled NNK[1].

NNK (Standard)	Endogenous Metabolite	Cancer
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

HY-126477S1

NNK-d3	Isotope-Labeled Compounds	Cancer
NNK-d3 is the deuterium labeled NNK (HY-126477) .

PBITC 4-Phenylbutyl isothiocyanate	Drug Derivative	Cancer
PBITC (4-Phenylbutyl isothiocyanate) is an orally active antitumor agent, and inhibits NNK (HY-126477) induced lung tumors in mice. PBITC is a thio-analog of the apoptosis inducer ISC-4 (HY-118375) .

Garlic oil	Apoptosis Reactive Oxygen Species	Cancer
Garlic oil contains various organosulfur compounds with anticancer activities. Garlic oil can significantly activate apoptosis in lung tissue induced by NNK (HY-126477). Furthermore, Garlic oil can markedly reduce NNK-induced DNA damage and prevent the occurrence of lung cancer by inducing the expression of phase II drug-metabolizing enzymes (HO-1, NQO-1, and GSTA1) .

LQEEIDAVL(Pro-13C5,15N)NK TFA	Isotope-Labeled Compounds	Others
LQEEIDAVL(Pro- ¹³C₅, ¹⁵N)NK TFA is the ¹³C- and ¹⁵N-labeled LQEEIDAVL(Pro)NK TFA.

Cat. No.	Product Name	Category	Target	Chemical Structure

*NNK* 1 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

NNK (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Endogenous Metabolite
NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure .

Garlic oil	Structural Classification Natural Products Source classification Allium sativum L. Plants Amaryllidaceae	Apoptosis Reactive Oxygen Species
Garlic oil contains various organosulfur compounds with anticancer activities. Garlic oil can significantly activate apoptosis in lung tissue induced by NNK (HY-126477). Furthermore, Garlic oil can markedly reduce NNK-induced DNA damage and prevent the occurrence of lung cancer by inducing the expression of phase II drug-metabolizing enzymes (HO-1, NQO-1, and GSTA1) .

Cat. No.	Product Name	Chemical Structure

NNK-d4
NNK-d₄ is the deuterium labeled NNK[1].

HY-126477S1

NNK-d3
NNK-d3 is the deuterium labeled NNK (HY-126477) .

LQEEIDAVL(Pro-13C5,15N)NK TFA
LQEEIDAVL(Pro- ¹³C₅, ¹⁵N)NK TFA is the ¹³C- and ¹⁵N-labeled LQEEIDAVL(Pro)NK TFA.

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