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Nav1.7-IN-18

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Sodium Channel (5)
By Research Areas:	Cancer (1) Inflammation/Immunology (2) Neurological Disease (4)

5

Inhibitors & Agonists

1

Natural
Products

Targets Recommended: Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Funapide TV 45070; XEN402	Sodium Channel	Neurological Disease Inflammation/Immunology
Funapide (TV 45070; XEN402) is a potent inhibitor of the sodium channel *Nav1.7, Nav1.8* and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent .

(R)-Funapide (R)-TV 45070; (R)-XEN402	Sodium Channel	Neurological Disease Inflammation/Immunology
(R)-Funapide ((R)-TV 45070) is the less active R-enantiomer of Funapide. Funapide is a potent inhibitor of the sodium channel *Nav1.7, Nav1.8* and other Nav channels expressed in the peripheral nervous system. Fornabil is an orally effective analgesic agent .

ABBV-318	Sodium Channel	Neurological Disease
ABBV-318 is a potent *Nav1.7/ Nav1.8* blocker, with IC₅₀s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain .

*Nav1.7-IN-18*	Sodium Channel	Cancer
Nav1.7-IN-18 (Compound 31) is a *Nav1.7* inhibitor with a K_i value of 4.9 nM and an IC₅₀ of 13 nM, showing analgesic effects in transgenic mice with inherited erythromelalgia (IEM) .

3'-Methoxydaidzein	Sodium Channel	Neurological Disease
3'-Methoxydaidzein is a isoflavone and a Sodium Channel inhibitor. 3'-Methoxydaidzein inhibits subtypes NaV1.7, NaV1.8 and NaV1.3 with IC₅₀ of 181 nM, 397 nM, and 505 nM, respectively. 3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels .

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