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Octyl-α-ketoglutarate

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114333
    Octyl-α-ketoglutarate

    1-Octyl 2-oxopentanedioate

    		 HIF/HIF Prolyl-Hydroxylase Cancer
    Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly in HEK293 cells with a dysfunctional TCA cycle, stimulating PHD activity. In addition, Octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD .
    Octyl-α-ketoglutarate
  • HY-145452
    5-Octyl-α-ketoglutarate

    5-Octyl 2-oxopentanedioate

    		 Others Cancer
    5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide (HY-A0003)-induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation .
    5-Octyl-α-ketoglutarate

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