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Results for "

Orai1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) CRAC Channel (6) Interleukin Related (2) Small Interfering RNA (siRNA) (1) TRP Channel (1)
By Research Areas:	Cardiovascular Disease (3) Inflammation/Immunology (3) Neurological Disease (1)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

MRS1845 1 Publications Verification	Calcium Channel CRAC Channel	Cardiovascular Disease
MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC₅₀ of 1.7 μM ^[1]. MRS1845 is an *ORAI1* inhibitor . MRS1845 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

RO2959 monohydrochloride 1 Publications Verification	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 monohydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 monohydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 monohydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[1] .

Zegocractin Maximum Cited Publications 11 Publications Verification CM-4620	CRAC Channel	Neurological Disease
Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor, with IC₅₀s of 119 nM and 895 nM for *Orai1/STIM1* and Orai2/STIM1 channels, respectively ^[1].

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels ^[1].

GSK-5498A 3 Publications Verification	CRAC Channel	Inflammation/Immunology
GSK-5498A is a selective CARC channel inhibitor (IC₅₀: 1 μM). GSK-5498A inhibits mediators release from mast cells and pro-inflammatory cytokines release from T cells. GSK-5498A can be used in the research of inflammatory disorders ^[1].

ORAI1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ORAI1 Human Pre-designed siRNA Set A contains three designed siRNAs for ORAI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ORAI1 Human Pre-designed siRNA Set A ORAI1 Human Pre-designed siRNA Set A

GSK-5503A	CRAC Channel	Inflammation/Immunology
GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders ^[1].

RO2959 hydrochloride	CRAC Channel Interleukin Related	Cardiovascular Disease
RO2959 hydrochloride is a potent and selective CRAC channel inhibitor with an IC₅₀ of 402 nM. RO2959 hydrochloride is a potent blocker of store operated calcium entry (SOCE) mediated by Orai1/Stim1 channels with an IC₅₀ of 25 nM. RO2959 hydrochloride is also a potent inhibitor of human IL-2 production, and potently blocks T cell receptor triggered gene expression and T cell functional pathways ^[1] .

Cat. No.	Product Name	Target	Research Area

*Anti-Orai1* Antibody**	Inhibitory Antibodies	Inflammation/Immunology
Anti-Orai1 Antibody is a humanized antibody expressed in CHO cells that targets *Orai1. The Anti-Orai1* Antibody has a huIgG2 heavy chain and a huλ light chain, with an predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-Orai1 Antibody can refer to Human IgG2 kappa, Isotype Control (HY-P99002).

Cat. No.	Compare	Product Name	Application	Reactivity

	ORAI1 Antibody (YA3157) CRACM1; Orai 1; Orai calcium release activated calcium modulator 1; Orai1; ORAT1; Protein Orai 1; TMEM142A	WB	Human
	ORAI1 Antibody (YA3157) is a biotin-conjugated non-conjugated IgG antibody, targeting ORAI1, with a predicted molecular weight of 33 kDa. ORAI1 Antibody (YA3157) can be used for WB experiment in human background.

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Cat. No.	Product Name		Classification

MRS1845 1 Publications Verification		Alkynes
MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC₅₀ of 1.7 μM ^[1]. MRS1845 is an *ORAI1* inhibitor . MRS1845 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

ORAI1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
ORAI1 Human Pre-designed siRNA Set A contains three designed siRNAs for ORAI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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