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Results for "

PFKFB3

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153077
    PFKFB3-IN-2

    		Phosphatase Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    PFKFB3-IN-2 is a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) inhibitor. PFKFB3-IN-2 has potential applications in cancer, neurodegenerative diseases, autoimmune diseases, inflammatory diseases, multiple sclerosis, metabolic diseases, angiogenesis inhibition and other diseases .
    PFKFB3-IN-2
  • HY-101971
    AZ PFKFB3 26
    1 Publications Verification

    		 Autophagy Cancer
    AZ PFKFB3 26 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 23 nM. AZ PFKFB3 26 inhibits PFKFB1 and PFKFB2 with IC50s of 2.06 and 0.384 μM, respectively .
    AZ PFKFB3 26
  • HY-101972
    AZ-PFKFB3-67
    1 Publications Verification

    		 Others Metabolic Disease
    AZ-PFKFB3-67 is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively .
    AZ-PFKFB3-67
  • HY-12204
    PFK-015
    3 Publications Verification

    		 Autophagy Metabolic Disease Inflammation/Immunology Cancer
    PFK-015, a derivative of 3PO, is a specific PFKFB3 inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. PFK-015 can be used for the research of multiple cancers such as lung cancer, stomach cancer, colon cancer and esophageal squamous cell carcinoma (ESCC) .
    PFK-015
  • HY-110156
    YZ9

    		Others Cancer
    Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM. Y29 also inhibits the HeLa cell growth with a GI50 of 2.7 µM .
    YZ9
  • HY-112808
    KAN0438757
    3 Publications Verification

    		 Autophagy Cancer
    KAN0438757 is a potent and selective inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM .
    KAN0438757
  • HY-12203
    PFK-158
    5+ Cited Publications

    		 Autophagy Apoptosis Cancer
    PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria [3].
    PFK-158
  • HY-19824
    3PO
    Maximum Cited Publications
    21 Publications Verification

    		 Autophagy Cancer
    3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD + and NADH. 3PO can be used for the research of cancer .
    3PO
  • HY-RS10363
    PFKFB3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    PFKFB3 Human Pre-designed siRNA Set A contains three designed siRNAs for PFKFB3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    PFKFB3 Human Pre-designed siRNA Set A
    PFKFB3 Human Pre-designed siRNA Set A
  • HY-101972A
    AZ-PFKFB3-67 quarterhydrate

    		Others Metabolic Disease
    AZ-PFKFB3-67 quarterhydrate is potent and selective metabolic kinase PFKFB3 inhibitor, with IC50s of 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively .
    AZ-PFKFB3-67 quarterhydrate
  • HY-123981
    5MPN

    		Phosphatase Cancer
    5MPN is a first-in-class, potent, orally active and selective 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) inhibitor. 5MPN appears to be a competitive inhibitor of the F6P binding site (Ki=8.6 μM). 5MPN does not inhibit PFK-1 or PFKFB3. 5MPN targets the sugar metabolism of tumors and suppresses proliferation of multiple human cancer cell lines .
    5MPN

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