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PIKfyve Kinase Inhibitor

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-154956
    PIKfyve-IN-2

    		PIKfyve Inflammation/Immunology Cancer
    PIKfyve-IN-2 is a potent PIKfyve kinase inhibitor and can be used for cancers, autoimmune disorders research .
    PIKfyve-IN-2
  • HY-163133
    PIKfyve-IN-3

    		PIKfyve Cancer
    PIKfyve-IN-3 (compound L22) has a remarkable interaction with PIKfyve kinase with a Kd value of 0.47 nM. PIKfyve-IN-3 has oral activity. PIKfyve-IN-3 inhibits tumor growth in a HeLa xenograft model .
    PIKfyve-IN-3
  • HY-151473
    PIKfyve-IN-1

    		PIKfyve Infection Cancer
    PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology . PIKfyve-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    PIKfyve-IN-1
  • HY-14644B
    Apilimod hydrochloride

    STA 5326 hydrochloride; LAM-002A (free base) hydrochloride; AIT-101 hydrochloride

    		 NOD-like Receptor (NLR) Infection Inflammation/Immunology
    Apilimod (STA 5326) hydrochloride is a PIKFYVE kinase inhibitor that promotes NLRP3 inflammatory vesicle activation and IL-1β secretion. Apilimod hydrochloride has been shown to inhibit host cell proteases, which may prevent viral invasion but also block antiviral immune responses, potentially exacerbating immunosuppression in COVID-19.
    Apilimod hydrochloride

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