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Results for "

PRC1-IN-1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19817
    PRT4165
    5+ Cited Publications

    NSC600157

    		 E1/E2/E3 Enzyme Cancer
    PRT4165 is a potent inhibitor of polycomb-repressive complex 1 (PRC1)-mediated H2A ubiquitylation.
    PRT4165
  • HY-170823
    PRC1-IN-1

    		E1/E2/E3 Enzyme Others
    PRC1-IN-1 (compound RB-4) is an inhibitor of the polycomb repressive complex PRC1 (IC50=2.3 μM), targeting RING1B-BMI1, RING1A-BMI1, and RING1B-PCGF1 with IC50s of 2.8, 2.6, and 1.8 μM, respectively .
    PRC1-IN-1
  • HY-158771
    PRC1 ligand 1

    		Ligands for Target Protein for PROTAC Cancer
    PRC1 ligand 1 is a target protein ligand of MS147 (HY-160924). PRC1 ligand 1 can be used to study cancer .
    PRC1 ligand 1
  • HY-160924
    MS147

    		PROTACs E1/E2/E3 Enzyme Cancer
    MS147 is a VHL-based PROTAC degrader of PRC1 (Polycomb Repressive Complex 1). The dissociation constants (Kd) of MS147 for EED (Embryonic Ectoderm Development) and VHL (Von Hippel-Lindau) are 3.0 μM and 450 nM, respectively. MS147 specifically binds to the EED protein through its EED-binding moiety; EED is a core component of PRC2 (Polycomb Repressive Complex 2) and interacts with the core components of PRC1, BMI1 (B-lymphoma Mo-MLV insertion region 1 homolog) and RING1B (Ring Finger Protein 1B). By this binding, MS147 is able to recruit BMI1 and RING1B near to VHL. Through the degradation of BMI1 and RING1B, MS147 reduces the level of H2AK119ub (histone H2A lysine 119 ubiquitination), affecting the proliferation of cancer cells. (Blue: VHL ligand (HY-125845), Black: linker ; Pink: PRC1 ligand (HY-158771)) .
    MS147