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Pathways Recommended: PROTAC
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PROTAC FGFR2 degrader 1

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163985
    PROTAC FGFR2 degrader 1

    		PROTACs FGFR Apoptosis Cancer
    PROTAC FGFR2 degrader 1 (compound N5) is a PROTAC that effectively targets FGFR2 with DC50 of 6.46 nM, the FGFR2 IC50 is 0.08 nM. PROTAC FGFR2 degrader 1 has anti-proliferative activity and highly selective, induces G0/G1 arrest of KATOIII and SNU16 cell cycle and inhibits apoptosis by reducing the activation of p-ERK and p-PLCγ, the downstream proteins of FGFR2. PROTAC FGFR2 degrader 1 inhibits gastric cancer cells remained above 50% at a concentration of 0.17 nM. PROTAC FGFR2 degrader 1 potently inhibits the growth of SNU16 xenograft tumors in mouse model (Structure Note: Pink, FGFR2 activator: HY-18708; Blue, E3 ligase ligand: HY--10984; Black, linker: HY-163989; E3 ligase ligand + linker：HY-163986) .
    PROTAC FGFR2 degrader 1
  • HY-162626
    FGFR2 degrader 1

    		PROTACs FGFR Cancer
    FGFR2 degrader 1 (compound 28E) is a selectively PROTACS degrader of FGFR2, with the DC50 of 0.645 nM. FGFR2 plays an important role in cancer research (Pink: ligand of target protein; (HY-13304) black: linker; blue: ligand of E3 ligase) .
    FGFR2 degrader 1
  • HY-163989
    N-Ethylheptanamide

    		PROTAC Linkers Cancer
    N-Ethylheptanamide is a PROTAC linker. N-Ethylheptanamide can be used in synthesis PROTAC FGFR2 degrader 1 (HY-163985) .
    N-Ethylheptanamide
  • HY-163986
    Pomalidomide-C2-NHCO-C6

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-C2-NHCO-C6 is an E3 Ligase Ligand-Linker Conjugate. Pomalidomide-C2-NHCO-C6 can be used to synthesize PROTAC FGFR2 degrader 1 (HY-163985) .
    Pomalidomide-C2-NHCO-C6

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