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Pathways Recommended: PROTAC
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PROTAC KDM4 degrader-1

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173135
    PROTAC KDM4 degrader-1

    		PROTACs Histone Demethylase Cancer
    PROTAC KDM4 degrader-1 (Compound 11) is a KDM4-targeted proteolysis targeting chimeras (PROTAC) degrader. PROTAC KDM4 degrader-1 can degrade KDM4A-C while sparing KDM4D. PROTAC KDM4 degrader-1 exhibits potent antiproliferative activity in esophageal cancer cells. PROTAC KDM4 degrader-1 induces apoptosis and cell cycle arrest, and inhibits histone H3 lysine demethylation. (Blue: E3 ligase ligand (HY-112078), Black: linker (HY-W013381); Pink: ligand for target protein (HY-173136) ) .
    PROTAC KDM4 degrader-1
  • HY-173137
    KDM4 Ligand-Linker Conjugate 1

    		Target Protein Ligand-Linker Conjugates Others
    KDM4 Ligand-Linker Conjugate 1 is a conjugate of a KDM4 target protein ligand and a linker, and can be used for the synthesis of PROTAC KDM4 degrader-1 (HY-173135) .
    KDM4 Ligand-Linker Conjugate 1
  • HY-W013381
    10-Bromodecanoic acid

    Decanoic acid, 10-bromo-

    		 PROTAC Linkers Others
    10-Bromodecanoic acid (Decanoic acid, 10-bromo-) is a linker that can be used in the synthesis of PROTACs, such as PROTAC KDM4 degrader-1 (HY-173135) .
    10-Bromodecanoic acid

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