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Pathways Recommended:	PROTAC

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PROTAC Sirt2 Degrader-1

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Targets Recommended: PROTAC Linkers PROTAC-Linker Conjugates for PAC Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

**PROTAC Sirt2 Degrader-1** 1 Publications Verification	Sirtuin PROTACs	Cancer
PROTAC Sirt2 Degrader-1 is a SirReal-based *PROTAC, acts as a Sirt2* degrader, composed of a highly potent and isotype-selective *Sirt2* inhibitor, a linker, and a bona fide Cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC₅₀ of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC₅₀s>100 μM) .

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