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PVD-06

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149760
    PVD-06

    		PROTACs Phosphatase Cancer
    PVD-06 is a selective PROTAC-class PTPN2 degrader (PTPN2/PTP1B selectivity index >60-fold) with anticancer activity. PVD-06 induces PTPN2 degradation via ubiquitination and proteasome-dependent pathways. PVD-06 can promote T cell activation and amplify IFN-γ-mediated cytotoxicity . PVD-06 consists of a target protein ligand (red part) PTPN2 ligand 1 (HY-168691), a PROTAC linker (black part) 6-Aminocaproic acid (HY-B0236), and an E3 ubiquitin ligase ligand (blue part) (S,R,S)-AHPC-Me (HY-112078). E3 ubiquitin ligase+linker can form 6-Aminocaproic acid-(S,R,S)-AHPC-Me (HY-168690).
    PVD-06
  • HY-168691
    PTPN2 ligand 1

    		Ligands for Target Protein for PROTAC Cancer
    PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760) .
    PTPN2 ligand 1
  • HY-168690
    6-Aminocaproic acid-(S,R,S)-AHPC-Me

    		E3 Ligase Ligand-Linker Conjugates Cancer
    6-Aminocaproic acid-(S,R,S)-AHPC-Me is a ligand and linker for the E3 ubiquitin ligase of PROTAC, which can be used to synthesize PVD-06 (HY-149760) and is used in tumor research .
    6-Aminocaproic acid-(S,R,S)-AHPC-Me

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