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Piericidin A

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114936
    Piericidin A
    3 Publications Verification

    AR-054

    		 Bacterial ADC Cytotoxin Antibiotic Mitochondrial Metabolism Infection Neurological Disease Cancer
    Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .
    Piericidin A
  • HY-133541
    Glucopiericidin A

    		GLUT ADC Cytotoxin Apoptosis Cancer
    Glucopiericidin A is a natural piericidin compound obtained from a marine-derived Streptomyces strain. Glucopiericidin A serves as a glucose transporter (GLUT) chemical probe and suppresses glycolysis. Glucopiericidin A inhibits ATP-dependent filopodia protrusion with Piericidin A (PA; HY-114936) and has no effect alone. Glucopiericidin A induces cell apoptosis through reducing the reactive oxygen species (ROS) level by increasing PRDX1 and exhibits potent antitumor efficacy in ACHN mice xenografts .
    Glucopiericidin A
  • HY-N12223
    Piericidin B

    		Antibiotic Bacterial Infection
    Piericidin B (compound 8) is an antibiotic that provides strong antibacterial defense for wasp larvae .
    Piericidin B

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