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Isoforms Recommended:	RGS4

Results for "

RGS4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Epigenetic Reader Domain (1) Histone Acetyltransferase (1) RGS Protein (5) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (1) Inflammation/Immunology (3) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CCG-63802 1 Publications Verification	RGS Protein	Inflammation/Immunology Cancer
CCG-63802 is a selective, reversible and allosteric *RGS4* inhibitor. CCG-63802 specifically binds to *RGS4* and blocks the RGS4-Gα_o interaction, with an IC₅₀ value of 1.9 μM .

CCG 203769	RGS Protein	Neurological Disease
CCG 203769 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gα_o protein-protein interaction in vitro with an IC₅₀ of 17 nM.

CCG-50014 2 Publications Verification	RGS Protein	Inflammation/Immunology
CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC₅₀ =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test .

PF-CBP1 hydrochloride 1 Publications Verification	Epigenetic Reader Domain Histone Acetyltransferase	Neurological Disease
PF-CBP1 hydrochloride is a highly selective inhibitor of the CREB binding protein bromodomain (CBP BRD). PF-CBP1 inhibits CREBBP and EP300 bromodomains with?IC₅₀?of 125 nM and 363 nM respectively. PF-CBP1 hydrochloride reduces LPS-induced inflammatory cytokines expression (IL-1β,?IL-6?and?IFN-β) in primary macrophages. PF-CBP1 hydrochloride also downregulates?RGS4?expression cortical neurons and can be used for the research of neurological disorders, including epilepsy and parkinson's disease, et al .

Rgs4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rgs4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rgs4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rgs4 Mouse Pre-designed siRNA Set A Rgs4 Mouse Pre-designed siRNA Set A

RGS4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RGS4 Human Pre-designed siRNA Set A contains three designed siRNAs for RGS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RGS4 Human Pre-designed siRNA Set A RGS4 Human Pre-designed siRNA Set A

Rgs4 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rgs4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rgs4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rgs4 Rat Pre-designed siRNA Set A Rgs4 Rat Pre-designed siRNA Set A

CCG-2046	RGS Protein	Inflammation/Immunology
CCG-2046 is a *RGS4* inhibitor with an IC₅₀ of 4.3 μM against RGS4-Gα_o interaction signal .

CCG-4986	RGS Protein	Others Neurological Disease
CCG-4986 is an RGS protein inhibitor. CCG-4986 inhibits protein activity by covalently modifying the Cys-132 site of RGS4. CCG-4986 can be used to study diseases related to dysregulated G protein-coupled receptor (GPCR) signaling, such as Parkinson's disease and opioid addiction .

Rgs4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Rgs4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rgs4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

RGS4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
RGS4 Human Pre-designed siRNA Set A contains three designed siRNAs for RGS4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rgs4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Rgs4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rgs4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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