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Ran-IN-1

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173350
    Ran-IN-1

    		Arf Family GTPase Cancer
    Ran-IN-1 (Compound M36) is an orally active and selective Ran GTPase inhibitor. Ran-IN-1 binds to the GDP-bound form of Ran (RanGDP) at the allosteric switch II pocket with high specificity, stabilizing the inactive state and reducing the active Ran-GTP population. Ran-IN-1 induces apoptosis and represses DNA repair pathways like HR and NHEJ in epithelial ovarian cancer (EOC) cells. Ran-IN-1 is promising for research of EOC, particularly high-grade serous carcinoma [1].
    Ran-IN-1

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