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Results for "

RyR2

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

4

Peptides

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-149662
    TMDJ-035

    		Calcium Channel Cardiovascular Disease Inflammation/Immunology
    TMDJ-035 is a selective RyR2 inhibitor. TMDJ-035 suppresses abnormal Ca 2+ waves and transients in isolated cardiomyocytes from RyR2-mutated mice. TMDJ-035is a tool for studying the mechanism and dynamics of RyR2 channel gating .
    TMDJ-035
  • HY-N7491A
    Ent-(+)-Verticilide

    		Calcium Channel Cancer
    ent-(+)-verticilide is a potent and selective inhibitor of cardiac ryanodine receptor (RyR2) calcium release channels with antiarrhythmic activity. ent-(+)-verticilide inhibits RyR2-mediated diastolic Ca 2+?leak and exhibits higher potency and a distinct mechanism of action compared with theDantrolene and Tetracaine.?ent-(+)-verticilide is a useful tool to investigate the therapeutic potential of targeting RyR2 hyperactivity in heart and brain pathologies .
    Ent-(+)-Verticilide
  • HY-15292
    S107
    1 Publications Verification

    		 Calcium Channel Cardiovascular Disease
    S107 is an orally available, blood brain barrier-permeable compound, which stabilizes RyR2 channels by enhancing the binding of calstabin 2 to the mutant Ryr2-R2474S channel. S107 inhibits Ca 2+ leakage from the sarcoplasmic reticulum (SR) and prevents cardiac arrhythmias and raises the seizure threshold [2].
    S107
  • HY-119850
    Aladorian

    ARM036

    		 Calcium Channel Cardiovascular Disease
    Aladorian (ARM036) is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian is a ryanodine receptor (RyR2) blocker. Aladorian is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia [2] .
    Aladorian
  • HY-149779
    RyR2 stabilizer-1

    		Calcium Channel Cardiovascular Disease
    RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca 2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca 2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias .
    RyR2 stabilizer-1
  • HY-RS12369
    RYR2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    RYR2 Human Pre-designed siRNA Set A contains three designed siRNAs for RYR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    RYR2 Human Pre-designed siRNA Set A
    RYR2 Human Pre-designed siRNA Set A
  • HY-P5319
    MCaE12A

    		Others Calcium Channel Others
    MCaE12A is a high-affinity modulator of RyR2 and increases RyR2 sensitivity to cytoplasmic calcium concentrations promoting channel opening. MCaE12A acts as an important tool for RyR2 structure-to-function studies as well as for manipulating Ca2+ homeostasis and dynamic of cardiac cell .
    MCaE12A
  • HY-119850A
    Aladorian sodium

    ARM036 sodium

    		 Calcium Channel Cardiovascular Disease
    Aladorian (ARM036) sodium is a benzothiazepine derivative, with anti-arrhythmia effect. Aladorian sodium is a ryanodine receptor (RyR2) blocker. Aladorian sodium is used for the research of heart failure and catecholaminergic polymorphic ventricular tachycardia [2] .
    Aladorian sodium
  • HY-Z7733
    O-Desmethylcarvedilol

    Desmethylcarvedilol; BM-14242

    		 Calcium Channel Metabolic Disease
    O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2 R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively) [2].
    O-Desmethylcarvedilol
  • HY-P5114
    Maurocalcine

    		Calcium Channel Others
    Maurocalcine is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine can be applied to in vivo cell tracking or other cell imaging techniques [2] .
    Maurocalcine
  • HY-P5114A
    Maurocalcine TFA

    		Calcium Channel Others
    Maurocalcine TFA is an agonist of ryanodine receptor (RyR) channel types 1, 2 and 3 with cellular permeability. Maurocalcine TFA induces [ 3H]ryanodine binding on RyR1 with an EC50 value of 2558 nM. Maurocalcine TFA exhibits a apparent affinity of 14 nM for RyR2. Maurocalcine TFA can be applied to in vivo cell tracking or other cell imaging techniques [2] .
    Maurocalcine TFA
  • HY-103059
    SOICR-IN-1

    		Calcium Channel Cardiovascular Disease
    SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC50 value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .
    SOICR-IN-1

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