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Results for "

SAMHD1

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161296
    TH6342

    		Bacterial HIV Infection
    TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe [1].
    TH6342
  • HY-B1299A
    Cephalosporin C zinc salt

    		Bacterial Orthopoxvirus Antibiotic Infection Inflammation/Immunology
    Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM [1]. Cephalosporin C zinc salt also has moderate anti-orthopoxvirus activity .
    Cephalosporin C zinc salt
  • HY-RS12433
    SAMHD1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SAMHD1 Human Pre-designed siRNA Set A contains three designed siRNAs for SAMHD1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SAMHD1 Human Pre-designed siRNA Set A
    SAMHD1 Human Pre-designed siRNA Set A
  • HY-137618B
    Rp-dGTPαS

    		Others Others
    Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates [1].
    Rp-dGTPαS
  • HY-137613
    Sp-TTPαS

    		HIV Infection Inflammation/Immunology
    Sp-TTPαS is a competitivesterile alpha motif and HD domain containing protein 1 (SAMHD1) catalysis inhibitor. Sp-TTPαS competitively inhibits TTP hydrolysis with a Ki value of 46 µM [1].
    Sp-TTPαS

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