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Results for "

SCAP

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0288
    Lycorine
    10+ Cited Publications

    		 Fatty Acid Synthase (FASN) Virus Protease Bacterial Apoptosis Inflammation/Immunology Cancer
    Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription . Lycorine is also a melanoma vasculogenic inhibitor . Lycorine can be used for the study of prostate cancer and metabolic diseases .
    Lycorine
  • HY-14452
    Fatostatin
    Maximum Cited Publications
    28 Publications Verification

    125B11

    		 Fatty Acid Synthase (FASN) Cancer
    Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
    Fatostatin
  • HY-14452A
    Fatostatin hydrobromide
    Maximum Cited Publications
    28 Publications Verification

    125B11 hydrobromide

    		 Fatty Acid Synthase (FASN) Cancer
    Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
    Fatostatin hydrobromide
  • HY-RS12484
    SCAP Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SCAP Human Pre-designed siRNA Set A contains three designed siRNAs for SCAP gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SCAP Human Pre-designed siRNA Set A
    SCAP Human Pre-designed siRNA Set A
  • HY-149658
    SREBP/SCAP-IN-2

    		Fatty Acid Synthase (FASN) Metabolic Disease
    SREBP/SCAP-IN-2(compound 13) is a selectiveSREBP/SCAPinhibitor .
    SREBP/SCAP-IN-2
  • HY-149657
    SREBP/SCAP-IN-1

    		Fatty Acid Synthase (FASN) Metabolic Disease
    SREBP/SCAP-IN-1(compound 10b) is a selectiveSREBP/SCAPinhibitor .
    SREBP/SCAP-IN-1
  • HY-W129441
    N-Acetyl-4-S-cysteaminylphenol

    N-Ac-4-S-CAP

    		 Others Others
    N-Acetyl-4-S-mercaptoaminophenol (N-Ac-4-S-CAP) is a compound that is selectively cytotoxic to melanocytes of black mouse hair follicles. It can cause 98% depigmentation of black mouse hair follicles. N-Ac-4-S-CAP can produce visible changes in hair follicle melanocytes 4 hours after intraperitoneal injection, including aggregation of melanin granules and nuclear condensation. Electron microscopy observations showed that it caused progressive destruction of melanocytes, including swelling of membranous organelles, nuclear condensation, and cytoplasmic vacuolation, ultimately leading to complete cell necrosis. N-Ac-4-S-CAP has a specific cytotoxic effect on melanocytes that actively produce eumelanin, but may not affect precursor or dormant melanocytes. These properties suggest that N-Ac-4-S-CAP may have potential application value in the treatment of melanoma or skin whitening.
    N-Acetyl-4-S-cysteaminylphenol

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