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Results for "

SCFFBXO22

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161794
    SP3N

    		FKBP Cancer
    SP3N is a specific degrader of proline isomerase FKBP12, which is metabolized by amine oxidase to a precursor of the active aldehyde (SP3CHO), which recruits SCFFBXO22 ligase for FKBP12 degradation. SP3N can be used in cancer therapy research .
    SP3N
  • HY-161795
    SP3CHO

    		Others Cancer
    SP3CHO is an active metabolite generated by the metabolism of SP3N in cell culture by the action of amine oxidase. SP3CHO can induce polyubiquitination of specific proteins by recruiting the SCFFBXO22 E3 ligase complex. SP3CHO can be used in cancer therapy research .
    SP3CHO
  • HY-161796
    UNC8732

    		Others Cancer
    UNC8732 is a targeted protein degradation (TPD) agent. It generates aldehyde metabolites through amine oxidase catalysis, which bind to C326 of the ubiquitin E3 ligase FBXO22, recruiting the SCFFBXO22 Cullin complex. The recruited FBXO22 further induces degradation of histone methyltransferases and the oncogene NSD2 .
    UNC8732

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