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SD 436

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-169360
    SD-436

    		PROTACs STAT
    SD-436 is a highly selective and efficacious STAT3 PROTAC degrader (DC50: 0.5 μM), with IC50 of 19 nM (STAT3), 270 nM (STAT1), 360 nM (STAT4), >10 μM (STAT5) and >10 μM (STAT6). SD-436 promotes ubiquitination and degradation of STAT3, and induces tumor regression. SD-436 can be used for tumor research, such as leukemia and lymphoma (Pink: STAT3 ligand (HY-169361); Blue: E3 ligase ligand (HY-43722); Black: linker (HY-147052) .
    SD-436
  • HY-169361
    STAT3 ligand 5

    		STAT Ligands for Target Protein for PROTAC Cancer
    STAT3 ligand 5 is a ligand for STAT3, that can be used as target protein ligand for synthesis of PROTAC degrader SD-436 (HY-169360) .
    STAT3 ligand 5
  • HY-169362
    Lenalidomide-Pip-butyn

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Lenalidomide-Pip-butyn is Lenalidomide (HY-A0003)-based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360) .
    Lenalidomide-Pip-butyn

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