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Results for "

SHMT

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Recombinant Proteins

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-129226
    SHMT-IN-2

    		SHMT Endocrinology Cancer
    SHMT-IN-2 is a stereo specific inhibitor of human SHMT1/2 with IC50 values of 13 nM and 66 nM for SHMT1 and SHMT2, respectively. SHMT-IN-2 can block the growth of many human cancer cells, and has sensitivity for B-cell lymphomas .
    SHMT-IN-2
  • HY-129651
    SHMT-IN-1

    		SHMT Cancer
    SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity .
    SHMT-IN-1
  • HY-112066
    SHIN1
    Maximum Cited Publications
    12 Publications Verification

    RZ-2994

    		 SHMT Cancer
    SHIN1 (RZ-2994) is a human serine hydroxymethyltransferse 1 and 2 (SHMT1/2) inhibitor with IC50s of 5 and 13 nM, respectively, in an in vitro assay.
    SHIN1
  • HY-134978
    (Rac)-SHIN2
    1 Publications Verification

    		 SHMT Others
    (Rac)-SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine hydroxymethyltransferase, respectively . (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (Rac)-SHIN2
  • HY-134978B
    (-)SHIN2

    		SHMT Cancer
    (-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (-)SHIN2
  • HY-134978A
    (+)SHIN2
    1 Publications Verification

    		 SHMT Cancer
    (+)SHIN2 is a serine hydroxymethyltransferase (SHMT) inhibitor, whose target can be traced with 13C-serine. (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (+)SHIN2
  • HY-162883
    SHMT-IN-4

    		SHMT Others
    SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC50 value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees .
    SHMT-IN-4
  • HY-RS12876
    SHMT1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SHMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SHMT1 Human Pre-designed siRNA Set A
    SHMT1 Human Pre-designed siRNA Set A
  • HY-RS12877
    SHMT2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SHMT2 Human Pre-designed siRNA Set A contains three designed siRNAs for SHMT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SHMT2 Human Pre-designed siRNA Set A
    SHMT2 Human Pre-designed siRNA Set A

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