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SP2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (1) Endogenous Metabolite (1) HDAC (1) Parasite (1) PKA (1) Potassium Channel (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

6

Inhibitors & Agonists

2

Peptides

1

Natural
Products

1

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SP2 Human Pre-designed siRNA Set A contains three designed siRNAs for SP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SP2 Human Pre-designed siRNA Set A SP2 Human Pre-designed siRNA Set A

Sp-2-Cl-cAMPS	PKA Parasite	Infection
Sp-2-Cl-cAMPS is an agonist for PKA with improved membrane permeability and stability to phosphodiesterase. Sp-2-Cl-cAMPS exhibits antimalarial activity, and inhibits the proliferation of Plasmodium falciparum with an EC₅₀ of 4 μM. Sp-2-Cl-cAMPS binds to purified P. falciparum PfPKAr (regulatory subunit of PfPKA) with a K_i of 1.3 µM .

SP-2-225	HDAC	Cancer
SP-2-225 is a selective HDAC6 inhibitor. SP-2-225 enhance the production of cancer-associated antigens and macrophage antigen cross-presentation to T cells. SP-2-225 reduces the tumor volume in a syngeneic SM1 melanoma model .

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

AChE-IN-57	Cholinesterase (ChE)	Neurological Disease
AChE-IN-57 (compound 5b(SP-2)) is a potent AChE inhibitor. AChE-IN-57 improves cognitive defects. AChE-IN-57 restores the biochemical mediators and inhibits reactive oxygen and nitrogen species implicated in the neuroinflammation mechanism. AChE-IN-57 has the potential for the research of Alzheimer .

Aspericin C	Endogenous Metabolite	Cancer
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

Cat. No.	Product Name	Target	Research Area

*SP2*	Peptides	Others
SP2 is a 14-amino acid long active peptide that can induce growth arrest in MTLa cells of the mating type locus of Candida albicans .

KTX-Sp2	Potassium Channel	Inflammation/Immunology
KTX-Sp2 is a potassium channel toxin. KTX-Sp2 effectively blocks three types of exogenous voltage-gated potassium channels: Kv1.1, Kv1.2 and Kv1.3. Ktx-Sp2 inhibits endogenous Kv1.3 and suppresses Ca ²⁺ signaling in Jurkat T cells. Ktx-Sp2 inhibits IL-2 secretion from activated Jurkat T cells .

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