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Serine hydroxymethyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SHMT (5) Antifolate (3) Apoptosis (3) Bcl-2 Family (3) Caspase (3) HDAC (1)
By Research Areas:	Cancer (7) Infection (1)

10

Inhibitors & Agonists

3

Recombinant Proteins

Targets Recommended: SHMT SRPK Ser/Thr Protease STK33 ASCT MASTL Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

SHMT-IN-1	SHMT	Cancer
SHMT-IN-1 (compound (±)-46) is a potent inhibitor of plasmodial serine hydroxymethyltransferase (SHMT). SHMT-IN-1 has antitumor activity .

(Rac)-SHIN2 1 Publications Verification	SHMT	Others
(Rac)-SHIN2 is a **serine hydroxymethyltransferase (SHMT*) inhibitor having 1,4-dihydropyrano[2,3-c]pyrazole structure. (Rac)-SHIN2 involves in folate or one-carbon metabolism pathways, prevents viral infection. SHMT1 and SHMT2 are the cytosolic and/or mitochondrial isoforms of serine* hydroxymethyltransferase, respectively . (Rac)-SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

SIS17 Maximum Cited Publications 6 Publications Verification	HDAC	Cancer
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs .

Lometrexol 1 Publications Verification DDATHF	Antifolate Apoptosis Caspase Bcl-2 Family	Cancer
Lometrexol (DDATHF), an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol has anticancer activity. Lometrexol also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .

Lometrexol hydrate 1 Publications Verification DDATHF hydrate	Antifolate Apoptosis Caspase Bcl-2 Family	Cancer
Lometrexol (DDATHF) hydrate, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol hydrate can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol hydrate has anticancer activity. Lometrexol hydrate also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .

Lometrexol disodium 1 Publications Verification DDATHF disodium	Antifolate Apoptosis Caspase Bcl-2 Family	Cancer
Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor .

(+)SHIN2 1 Publications Verification	SHMT	Cancer
(+)SHIN2 is a **serine hydroxymethyltransferase (SHMT*) inhibitor, whose target can be traced with ¹³C-serine.* (+)SHIN2 increases survival in NOTCH1-driven mouse primary acute lymphoblastic leukemia (T-ALL) in vivo with a synergistic effect with Methotrexate (HY-14519) . (+)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

(-)SHIN2	SHMT	Cancer
(-)SHIN2 is the isomer of (+)SHIN2 (HY-134978A). (+)SHIN2 is an inhibitor of serine hydroxymethyltransferase (SHMT) with antileukemic effect. (+)SHIN2 synergisty with and Methotrexate (HY-14519) in vivo xenotransplantation models . (-)SHIN2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

D-Homoserine lactone	Others	Infection
D-Homoserine lactone is a signaling molecule with the activity of regulating bacterial quorum sensing. The chemical structure of D-Homoserine lactone makes it a potential regulator of the AHL synthase RhlI. D-Homoserine lactone has been shown to inhibit the activity of RhlI, thereby affecting the bacterial quorum sensing signaling pathway. D-Homoserine lactone is also an enantiomer of L-homoserine lactone and is used as an inhibitor of serine hydroxymethyltransferase .

SHMT-IN-4	SHMT	Others
SHMT-IN-4 (Compound 9ay) is a herbicide that targets and inhibits serine hydroxymethyltransferase (SHMT1) with an IC₅₀ value of 193.8 g a.i./ha (active ingredient content per hectare). SHMT-IN-4 interferes with amino acid synthesis and metabolism in plants by binding to SHMT1, thereby inhibiting plant growth. Additionally, SHMT-IN-4 shows no significant toxicity to maize and honeybees .

Species:	Human (3)
Tag:	His (2) Tag Free (1)
Source:	HEK293 (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

	SHMT1 Protein, Human (HEK293, His) Serine hydroxymethyltransferase Cytosolic; SHMT; Glycine hydroxymethyltransferase; Serine Methylase; SHMT1	Human	HEK293
	SHMT1 Protein, Human (HEK293, His) is the recombinant human-derived SHMT1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SHMT1 Protein, Human (HEK293, His) is 481 a.a., with molecular weight of ~55.0 kDa.

	SHMT2 Protein, Human SHMT2; Serine hydroxymethyltransferase; mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase	Human	E. coli
	The SHMT2 protein catalyzes the cleavage of serine to produce 5,10-methylenetetrahydrofolate for purine synthesis. It binds to mitochondrial DNA and participates in target protein deubiquitination via the BRISC complex. SHMT2 Protein, Human is the recombinant human-derived SHMT2 protein, expressed by E. coli , with tag free. The total length of SHMT2 Protein, Human is 476 a.a., .

	SHMT2 Protein, Human (His) SHMT2; Serine hydroxymethyltransferase; mitochondrial; SHMT; Glycine hydroxymethyltransferase; Serine methylase	Human	E. coli
	The SHMT2 protein catalyzes the cleavage of serine to produce 5,10-methylenetetrahydrofolate for purine synthesis. It binds to mitochondrial DNA and participates in target protein deubiquitination via the BRISC complex. SHMT2 Protein, Human (His) is the recombinant human-derived SHMT2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of SHMT2 Protein, Human (His) is 476 a.a., .

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