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Results for "

Shank3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) PAK (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS12852

SHANK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SHANK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SHANK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SHANK3 Human Pre-designed siRNA Set A SHANK3 Human Pre-designed siRNA Set A

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

HY-163345

5-HT7R antagonist 2

5-HT Receptor

Neurological Disease

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a K_i of 67 nM, the IC₅₀ values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment .
Pharmacokinetic Analysis ICR Male Mice

药代动力学分析

Plasma	Intravenous Administration	Intraperitoneal Administration
T_max (h)	0.08	0.25
T_1/2 (h)	0.77	1.06
C_max (ng/mL)	33.07	156.44
AUC_last (ng·h/mL)	28.31	143.27
CL (L/h/kg)	41.61	-
V_ss (L/kg)	32.43	-
MRT (h)	0.79	0.93
F (%)	50.60

Cat. No.	Product Name	Target	Research Area

HY-P10106

TAT-PAK18 inhibitory peptide	PAK	Cancer
TAT-PAK18 inhibitory peptide is a membrane-permeable PAK inhibitory peptide. TAT-PAK18 inhibitory peptide reduces F-actin clusters and occludes the effect of Shank3 knockdown .

SHANK3 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
SHANK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SHANK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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