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Skp2-Cks1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-123578
    NSC689857
    1 Publications Verification

    		 EGFR E1/E2/E3 Enzyme Cancer
    NSC689857 is a potent EGFR and SCF SKP2 inhibitor with an IC50 value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC50=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others .
    NSC689857
  • HY-153937
    Skp2 inhibitor 2

    		E1/E2/E3 Enzyme Cancer
    Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC50 value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process .
    Skp2 inhibitor 2
  • HY-162938
    Skp2 inhibitor 3

    		E1/E2/E3 Enzyme Cancer
    Skp2 inhibitor 3 (E35), an antitumor agent, is a potent S‑Phase Kinase-associated Protein 2 (SKP2) inhibitor, with an IC50 of 4.86 μM for Skp2-Cks1 binding. Skp2 inhibitor 3 (E35) significantly inhibits colony formation and migration, as well as arrests the cell cycle at the S-phase .
    Skp2 inhibitor 3

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