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SpCas9

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRISPR/Cas9 (3)
By Research Areas:	Cancer (1) Infection (1)

3

Inhibitors & Agonists

3

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

BRD7586 1 Publications Verification	CRISPR/Cas9	Cancer
BRD7586 is a potent and selective **Streptococcus pyogenes Cas9 (SpCas9)** inhibitor. BRD7586 specifically engages SpCas9 but not Cas12a in cells and enhances SpCas9 specificity at multiple loci. BRD7586 inhibits SpCas9 at multiple genomic loci irrespective of the mode of SpCas9 delivery .

BRD0539	CRISPR/Cas9	Infection
BRD0539 is a Streptococcus pyogenes Cas9 (SpCas9) inhibitor with an IC₅₀ of 22 μM in an in vitro DNA cleavage assay .

SpCas9 D10A Nickase	CRISPR/Cas9	Others
SpCas9 D10A Nickase is a mutant of the Cas9 protein. SpCas9 D10A Nickase retains the function of a cleavage domain of Cas9 nuclease and specifically cleaves the target single strand to form a nick. SpCas9 D10A Nickase reduces off-target effects .

Tag:	His (2) Tag Free (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

	CRISPR-Cas9 Protein, S. pyogenes (His) CRISPR-associated endonuclease Cas9/Csn1; cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. CRISPR-Cas9 Protein, S. pyogenes (His) is the recombinant CRISPR-Cas9 protein, expressed by E. coli , with His tagged. The total length of CRISPR-Cas9 Protein, S. pyogenes (His) is 1367 a.a., with molecular weight of ~163 kDa.

	CRISPR-Cas9 Protein, S. pyogenes (NLS) CRISPR-associated endonuclease Cas9/Csn1; cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. CRISPR-Cas9 Protein, S. pyogenes (NLS) is the recombinant CRISPR-Cas9 protein, expressed by E. coli , with tag free. The total length of CRISPR-Cas9 Protein, S. pyogenes (NLS) is 1368 a.a., with molecular weight of ~160 kDa.

	GMP-CRISPR-Cas9 Protein, S. pyogenes (His) CRISPR-associated endonuclease Cas9/Csn1; cas9; SpCas9; SpyCas9	Others	E. coli
	The CRISPR-Cas9 protein is part of an immune system that defends against genetic elements. It processes RNA and aids in cleaving DNA targets. Protein and guide RNAs are necessary for its function. The protein recognizes specific sequences to distinguish self from nonself and provides immunity against matching genetic elements. GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is the recombinant GMP-CRISPR-Cas9 protein, expressed by E. coli , with His labeled tag. The total length of GMP-CRISPR-Cas9 Protein, S. pyogenes (His) is 1367 a.a., with molecular weight of ~163 kDa.

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