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Results for "

Specificity protein 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Bacterial (1) COX (1) DNA/RNA Synthesis (1) Fluorescent Dye (3) Glutathione S-transferase (1) NADPH Oxidase (1) NF-κB (1) p38 MAPK (1) PPAR (1) RIP kinase (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (1) Inflammation/Immunology (3) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Targets Recommended: DYRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W010983

SC-236 1 Publications Verification	COX PPAR Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
SC-236 is an orally active COX-2 specific inhibitor (IC₅₀ = 10 nM) and a PPARγ agonist. SC-236 suppresses activator protein-1 (AP-1) through c-Jun NH2-terminal kinase. SC-236 exerts anti-inflammatory effects by suppressing phosphorylation of ERK in a murine model .

HY-A0122

Plicamycin 25+ Cited Publications Mithramycin A	DNA/RNA Synthesis Bacterial Antibiotic Glutathione S-transferase	Infection Cancer
Plicamycin (Mithramycin A) is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits *GSTM2 promoter activity and protein* expression .**

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-148772

PTC258	Others	Neurological Disease
PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model .

HY-D0122

6-Iodoacetamidofluorescein	Fluorescent Dye	Others
6-Iodoacetamidofluorescein, a sulphhydryl-specific fluorescent dye, and can be used to selectively label the -SH groups of nuclear matrix polypeptides and proteins .

HY-W100287

Murrayafoline A	NF-κB p38 MAPK	Neurological Disease Inflammation/Immunology
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline A has anti-neuroinflammatory activity .

HY-156404

PM-1	Fluorescent Dye	Others
PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins .

HY-134308

8-NBD-cAMP sodium	Fluorescent Dye	Others
8-NBD-cAMP sodium is a fluorescently labeled cyclic adenosine phosphate (cAMP) analogue. 8-NBD-cAMP sodium retains a similar biological activity to cAMP, regulating their activity by binding to specific proteins such as EPACs or PKA. 8-NBD-cAMP sodium can be used in fluorescent competitive binding experiments to evaluate the binding affinity of newly synthesized EPAC1 agonists to EPAC1 proteins .

HY-100131

GSK481	RIP kinase	Inflammation/Immunology
GSK481 is a highly potent, selective, and specific *receptor interacting protein 1* (RIP1) kinase inhibitor with an IC₅₀ of 1.3 nM, which inhibits Ser ¹⁶⁶ phosphorylation in wild-type human RIP1 (IC₅₀=2.8 nM). GSK481 also exhibits excellent translation in the U937 cellular assay with an IC₅₀** of 10 nM .

Cat. No.	Product Name	Type

HY-156404

PM-1	Dyes
PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins .

PM-1

Dyes

PM-1, a derivative of Thioflavin-T (ThT; HY-D0218), is a small but highly specific plasma membrane (PM) fluorescent dye for specific and long-time membrane imaging of living and fixed cells. PM-1 is embedded directly into the cell membrane and exhibits a very long retention time on the plasma membrane with a half-life of approximately 15 h. PM-1 can be used in combination with protein labeling probes to study ectodomain shedding and endocytosis processes of cell surface proteins .

HY-D0122

6-Iodoacetamidofluorescein	Fluorescent Dyes/Probes
6-Iodoacetamidofluorescein, a sulphhydryl-specific fluorescent dye, and can be used to selectively label the -SH groups of nuclear matrix polypeptides and proteins .

Murrayafoline A	Structural Classification Alkaloids Murraya tetramera C. C. Huang Source classification Rutaceae Carbazole Alkaloids Plants	NF-κB p38 MAPK
Murrayafoline A is a carbazole alkaloid that can be extracted from Murraya tetramera. Murrayafoline A directly targets Specificity protein 1 (Sp1), thereby inhibiting NF-κB and MAPK signaling pathways. Murrayafoline A has anti-neuroinflammatory activity .

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