2. Protein Tyrosine Kinase/RTK Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. Bcr-Abl Apoptosis PARP
  4. EAPB0503

EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein .

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EAPB0503 Chemical Structure

EAPB0503 Chemical Structure

CAS No. : 1140627-77-5

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM). EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein [1] [2].

Molecular Weight

304.35

Formula

C18H16N4O
CAS No.
SMILES

COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
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EAPB0503 Related Classifications

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Keywords:

EAPB05031140627-77-5EAPB 0503EAPB-0503Bcr-AblApoptosisPARPpoly ADP ribose polymerasemelanoma cellsDNA fragmentationCML cellInhibitorinhibitorinhibit

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