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Results for "

Thalidomide-pyrrolidine

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-153220
    NX-2127

    		PROTACs Btk Cancer
    NX-2127 (compound 28) is an orally active PROTAC deggrader, targeting to Bruton’s Tyrosine Kinase (Btk) . NX-2127 inhibits proliferation of BTK C481S mutant TMD8 cells, more effectively than Ibrutinib (HY-10997). NX-2127 catalyzes the degradation of Ikaros (IKZF1) and Aiolos (IKZF3) with of 25 nM and 54 nM, respectively. NX-2127 stimulates T cell activation and increases IL-2 production in primary human T Cells . NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303). Among which, the conjugate of E3 ubiquitin ligase ligand + Linker compose of Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
    NX-2127
  • HY-W248665A
    Thalidomide-pyrrolidine hydrochloride

    		Ligands for E3 Ligase Cancer
    Thalidomide-pyrrolidine hydrochloride (compound 18) is an E3 ligase ligand, and can be used for synthesis of PROTACs .
    Thalidomide-pyrrolidine hydrochloride
  • HY-159599
    Thalidomide-pyrrolidine-C-azaspiro

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Thalidomide-pyrrolidine-C-azaspiro is an E3 Ligase Ligand-Linker Conjugate. Thalidomide-pyrrolidine-C-azaspiro can be used to synthesize CW-3308 (HY-159579) .
    Thalidomide-pyrrolidine-C-azaspiro
  • HY-168349
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2

    		E3 Ligase Ligand-Linker Conjugates Others
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the coupling conjugate of the E3 ubiquitin ligase ligand and linker for NX-2127 (HY-153220) .
    (S)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
  • HY-168304
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2

    		E3 Ligase Ligand-Linker Conjugates Cancer
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 is the E3 ubiquitin ligase ligand and linker of PROTAC (R)-NX-2127 (HY-153220A), which can be used in cancer research .
    (R)-Thalidomide-pyrrolidine-C-piperidine-Ph-NH2
  • HY-153220A
    (R)-NX-2127

    		PROTACs Btk Inflammation/Immunology Cancer
    (R)-NX-2127 ((R)-compound 28) is an isomer of the BTK PROTAC degrader NX-2127 (HY-153220) . (R)-NX-2127 is composed of PROTAC target protein ligand (red part) BTK ligand 10 (HY-168302), E3 ligase ligand (blue part) Thalidomide 5-fluoride (HY-W087383) and PROTAC Linker (black part) Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).
    (R)-NX-2127
  • HY-159579
    CW-3308

    		PROTACs Epigenetic Reader Domain Cancer
    CW-3308 is an orally effective PROTAC that selectively targets BRD9 and is expected to be used to inhibit synovial sarcoma, rhabdomyoma, and other BRD9-dependent human diseases. CW-3308 is composed of PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH (HY-159596) (red part), Linker 3-Azaspiro[5.5]undecane-9-methanol (HY-159598) (black part), E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine (HY-159597) (blue part), where the conjugate of E3 ubiquitin ligase ligand + linker is Thalidomide-pyrrolidine-C-azaspiro (HY-159599) [1] .
    CW-3308

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