2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Btk
  4. (R)-NX-2127

(R)-NX-2127 (compound 28) is a a PROTAC targeting Bruton’s Tyrosine Kinase (Btk) with oral activity. (R)-NX-2127 is composed of PROTAC target protein ligand BTK ligand 10 (HY-168302) (red part), E3 ligase ligand Thalidomide 5-fluoride (HY-W087383) (blue part) and PROTAC Linker (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304).

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(R)-NX-2127 Chemical Structure

(R)-NX-2127 Chemical Structure

CAS No. : 3024312-52-2

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-NX-2127:

(R)-NX-2127 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

(R)-NX-2127 (compound 28) is a a PROTAC targeting Bruton’s Tyrosine Kinase (Btk) with oral activity. (R)-NX-2127 is composed of PROTAC target protein ligand BTK ligand 10 (HY-168302) (red part), E3 ligase ligand Thalidomide 5-fluoride (HY-W087383) (blue part) and PROTAC Linker (S)-4-(1-(Pyrrolidin-3-ylmethyl)piperidin-4-yl)aniline (HY-168303) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-pyrrolidine-C-piperidine-Ph-NH2 (HY-168304)[1].

Molecular Weight

719.83

Formula

C39H45N9O5
CAS No.
SMILES

O=C1C2=CC(N3C[C@@H](CN4CCC(C5=CC=C(C=C5)NC6=C(N=CC(N7CCCCC7)=N6)C(N)=O)CC4)CC3)=CC=C2C(N1C8C(NC(CC8)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-NX-2127 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-NX-21273024312-52-2PROTACsBtkBruton tyrosine kinaseInhibitorinhibitorinhibit

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