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Results for "

VX-445

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

2

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111772
    Elexacaftor
    25+ Cited Publications

    VX-445

    		 CFTR Autophagy Inflammation/Immunology
    Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR). Elexacaftor (VX-445, Compound 1) facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface .
    Elexacaftor
  • HY-111772S1
    Elexacaftor-d3

    VX-445-d3

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Elexacaftor-d3 (VX-445-d3) is the deuterium labeled Elexacaftor (HY-111772) .
    Elexacaftor-d3
  • HY-15448
    Tezacaftor
    10+ Cited Publications

    VX-661

    		 CFTR Cancer
    Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .
    Tezacaftor
  • HY-111772A
    (R)-Elexacaftor

    (R)-VX-445

    		 CFTR Inflammation/Immunology
    (R)-Elexacaftor is an enantiomer of Elexacaftor (HY-111772). (R)-Elexacaftor is the Compound 37 from patent WO2018107100A1. (R)-Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR), the EC50 for CFTR dF508 is 0.29 uM .
    (R)-Elexacaftor
  • HY-111772S
    Elexacaftor-13C,d3

    VX-445-13C,d3

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Elexacaftor- 13C,d3 is the deuterium labeled Elexacaftor (HY-111772)[1].
    Elexacaftor-13C,d3

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