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Results for "

adduct

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Aldehyde Dehydrogenase (ALDH) (2) Aminoacyl-tRNA Synthetase (1) Antibiotic (3) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Bacterial (2) Bcr-Abl (1) Biochemical Assay Reagents (17) Btk (4) COX (2) Cytochrome P450 (1) DNA Alkylator/Crosslinker (5) DNA/RNA Synthesis (13) Drug Metabolite (3) Endogenous Metabolite (7) Epigenetic Reader Domain (1) Fluorescent Dye (4) Histone Acetyltransferase (1) Histone Methyltransferase (2) Isotope-Labeled Compounds (3) Lipase (1) MDM-2/p53 (2) Nucleoside Antimetabolite/Analog (3) Parasite (4) Reactive Oxygen Species (2) RGS Protein (2)
By Research Areas:	Cancer (38) Cardiovascular Disease (2) Infection (10) Inflammation/Immunology (9) Metabolic Disease (8) Neurological Disease (4)
Click Chemistry:	Azide (2)
Oligonucleotides:	Nucleosides and their Analogs (1) Polymers (9)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W273413

4-Hydrazino-7-nitro-benzofurazan hydrazine adduct NBD-H	Fluorescent Dye	Cancer
4-Hydrazino-7-nitro-benzofurazan hydrazine adduct is a fluorescent reagent for protein labeling.

HY-69014

2-O-Methylcytosine	DNA/RNA Synthesis Endogenous Metabolite	Cancer
2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents	Others
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-114713

POBN 4-POBN	Others	Others
POBN (4-POBN) is a cell permeable, hydrophilic spin trap that can be used to detect free radical adducts .

HY-157175

Mannosamine–lipoic acid adduct	Others	Others
Mannosamine-lipoic acid adduct is a hapten. Mannosamine-lipoic acid adduct with hsIgG conjugation significantly reduces the antibody immune response against hsIgG .

HY-157173

Mannosamine-biotin adduct	Others	Inflammation/Immunology
Mannosamine–biotin adduct is a hapten. Mannosamine–biotin adduct conjugated to hsIgG significantly reduces antibody immune responses against hsIgG .

HY-157174

Mannosamine–desthiobiotin adduct	Others	Inflammation/Immunology
Mannosamine-desthiobiotin adduct (compound MDTBA) is a carrier immunogenicity-reducing hapten that reduces the immunogenicity of protein carriers upon conjugation to available free amines on the carrier protein surface. Conjugation of Mannosamine-desthiobiotin adduct to hsIgG significantly (>1-fold) reduced the immunogenicity of hsIgG. Mannosamine-desthiobiotin adduct can be used in antigen design research .

HY-163036

Glucosamine–biotin adduct	Others	Inflammation/Immunology
Glucosamine-biotin adduct is a hapten and can be conjugated to hsIgG .

HY-167538

sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct	Biochemical Assay Reagents	Others
sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct is a biochemical reagent.

HY-W582827

*RuPhos Pd G1 methyl t-butyl ether adduct* (MTBE)**	Others
RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is a highly efficient catalyst with excellent cross-coupling activity. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) is widely used in organic synthesis and can be used to promote various reactions to build complex molecular structures. RuPhos Pd G1 methyl t-butyl ether adduct (MTBE) has good adaptability to temperature and reaction conditions, which enables it to exhibit excellent catalytic performance in different reaction systems.

HY-W683760

N-Nitrosonornicotine	DNA/RNA Synthesis	Cancer
N-Nitrosonornicotine is a tobacco-specific nitrosamine that has carcinogenic and mutagenic activity, and it can induce micronuclei in C3A cells. N-Nitrosonornicotine can form DNA adducts .

HY-W016433

2-Aminofluorene	DNA/RNA Synthesis	Others
2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis .

HY-119983

7H-Dibenzo[c,g]carbazole DBC	Others	Cancer
7H-Dibenzo[c,g]carbazole (DBC) is an azaarene with high lipophilicity. 7H-Dibenzo[c,g]carbazole has carcinogenic activity and induce DNA adducts in fish, DNA adducts, mutations in diploid human fibroblasts and micronuclei in human blood lymphocytes. 7H-Dibenzo[c,g]carbazole is activated by cytochrome P450 enzymes resulting mainly in the generation of phenolic metabolites .

HY-159103

LeuRS-IN-2	Aminoacyl-tRNA Synthetase	Infection
LeuRS-IN-2 (Compound 9) is a Wolbachia leucyl-tRNA synthetase (LeuRS) inhibitor in the presence of adenosine monophosphate (AMP) with an EC₅₀ value of 6 nM, efficiently arresting the growth of pathogenic host. LeuRS-IN-2 forms adenosine-based adducts inhibiting protein synthesis, which is promising for research of new antimicrobials with disrupting microbiota .

HY-U00279

Nitracrine	DNA/RNA Synthesis	Cancer
Nitracrine inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine, a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine has cytotoxicity towards most cells .

HY-U00279A

Nitracrine dihydrochloride hydrate	DNA/RNA Synthesis	Cancer
Nitracrine (dihydrochloride hydrate) inhibits RNA synthesis and covalently, reversibly binds to DNA but also forms covalent adducts with DNA in vivo. Nitracrine (dihydrochloride hydrate), a 1-nitroacridine derivative, is a potent hypoxia-selective agent in vitro and antitumor agent. Nitracrine (dihydrochloride hydrate) has cytotoxicity towards most cells .

HY-W013053

Dibenz[a,h]anthracene DBA; 1,2,5,6-Dibenzanthracene; Benzo[k]tetraphene	DNA/RNA Synthesis Apoptosis MDM-2/p53	Cancer
Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-128463

N-tert-Butyl-α-phenylnitrone 1 Publications Verification	COX Reactive Oxygen Species	Neurological Disease Metabolic Disease Inflammation/Immunology
N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier .

HY-W013053R

Dibenz[a,h]anthracene (Standard)	DNA/RNA Synthesis Apoptosis MDM-2/p53	Cancer
Dibenz[a,h]anthracene (Standard) is the analytical standard of Dibenz[a,h]anthracene. This product is intended for research and analytical applications. Dibenz[a,h]anthracene (DBA) is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms .

HY-U00279B

Nitracrine hydrochloride	DNA/RNA Synthesis	Cancer
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions and is approximately 100,000 times more potent than misonidazole. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .

HY-W141077

1-Nitrosopyrrolidine	Biochemical Assay Reagents	Others
1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.

HY-147740

WEHI-150	DNA Alkylator/Crosslinker	Cancer
WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkadduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .

HY-W141077R

1-Nitrosopyrrolidine (Standard)	Biochemical Assay Reagents	Others
1-Nitrosopyrrolidine (Standard) is the analytical standard of 1-Nitrosopyrrolidine. This product is intended for research and analytical applications. 1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.

HY-111375

Azoxymethane Maximum Cited Publications 10 Publications Verification AOM	DNA Alkylator/Crosslinker	Cancer
Azoxymethane is a colon carcinogen which leads to the formation of DNA adducts.

HY-N6828

Monocrotaline N-Oxide	Others	Metabolic Disease
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-139093A

Paracetamol-cysteine TFA	Others	Others
Paracetamol-cysteine (TFA) is an acetaminophen-protein adduct formed during the metabolism of acetaminophen (HY-66005) .

HY-118517

α-Hydroxytamoxifen (E)-α-Hydroxy tamoxifen; α-OHTAM	Drug Metabolite	Cancer
α-Hydroxytamoxifen is a metabolite of tamoxifen, reacts with DNA in the absence of metabolizing enzymes, and causes formation of DNA adducts .

HY-129480

Vertilmicin sulfate	Others	Others
Vertilmicin sulfate combines with FMOC-Cl to form the Vertilmicin-FMOC-Cl adduct, and can be used for the determination of glucosamine sulfate in plasma .

HY-116870

Vamidothion	Parasite	Infection
Vamidothion is a polar organophosphorus insecticide and acaricide with biological activity against insects and mites. Vamidothion is degraded by human serum albumin (HSA) and promotes adduct formation with tyrosine residues. The phosphate amino acid adducts formed after the reaction of vamidothion with HSA are detected by liquid chromatography quadrupole-Orbitrap mass spectrometry. The metabolites of vamidothion can be used in forensic toxicology to help determine deaths caused by organophosphorus poisoning .

HY-W587780

Sulfamethoxazole-NO SMX-NO	Others	Inflammation/Immunology
Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents .

HY-N0510A

Aristolochic acid sodium salt 5+ Cited Publications Aristolochic acid I sodium; TR 1736 sodium; Sodium aristolochate	Biochemical Assay Reagents	Others
Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a proagent that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.

HY-116832

Retrorsine N-oxide	Others	Cancer
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-124489

2-Hydroxyestradiol 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-116073

L-Penicillamine	Biochemical Assay Reagents	Metabolic Disease
L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

HY-W016286

2,6-Dithiopurine 2,6-Dimercaptopurine	Others	Cancer
2,6-Dithiopurine (2,6-Dimercaptopurine) is a nucleophilic scavenger for electrophilic carcinogens. 2,6-Dithiopurine abolishes both DNA adduct formation and the initiation of carcinogenesis .

HY-156883

Dasatinib analog-1	Cytochrome P450	Others
Dasatinib analog-1 (compound 5826) inhibits CYP3A4 viability with a K_i value of 5.4 μM. Dasatinib analog-1 blocks the formation of glutathione adducts .

HY-129846

IBTP iodide	Others	Others
IBTP iodide is a lipophilic cation and can be accumulated by mitochondria and yields stable thioether adducts in a thiol-specific reaction. IBTP iodide can be used for specific labeling of mitochondrial protein thiols .

HY-N6828R

Monocrotaline N-Oxide (Standard)	Others	Metabolic Disease
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-13036A

IBT6A	Btk	Cancer
IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-13036B

IBT6A hydrochloride	Btk	Cancer
IBT6A hydrochloride is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-D0017

Dansyl chloride DNSCl	Fluorescent Dye	Others
Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

HY-N0618

Sanggenon D	Lipase	Inflammation/Immunology
Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.

HY-N0769

Isopimpinellin 1 Publications Verification	DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .

HY-N3515

Multicaulisin	Bacterial	Infection
Multicaulisin, a new Diels-Alder type adduct from Morus multicaulis roots, potently effects against Staphylococcus aureus (MRSA) isolates. Multicaulisin is an antibacterial agent and has the potential for MRSA infections research .

HY-122251

CCG-4986	RGS Protein	Others Neurological Disease
CCG-4986 is an RGS protein inhibitor. CCG-4986 inhibits protein activity by covalently modifying the Cys-132 site of RGS4. CCG-4986 can be used to study diseases related to dysregulated G protein-coupled receptor (GPCR) signaling, such as Parkinson's disease and opioid addiction .

HY-133590

Heliotrine N-oxide	Others	Cancer
Heliotrine N-oxide is the corresponding PA (pyrrolizidine alkaloid) N-oxide of Heliotrine (HY-126128). Heliotrine N-oxide leads to the formation of pyrrolic DNA adducts and potential initiation of PA-induced liver tumors in vivo .

HY-W011640

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol	Others	Cancer
7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters , which are capable of forming covalent DNA adducts and inducing mutations .

HY-101160

SG2057 DRG16	DNA Alkylator/Crosslinker ADC Cytotoxin	Cancer
SG2057 (DRG16) is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent .

HY-13036

(Rac)-IBT6A	Btk	Cancer
(Rac)-IBT6A is a racemate of IBT6A. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

HY-13036C

(Rac)-IBT6A hydrochloride	Btk	Cancer
(Rac)-IBT6A hydrochloride is a racemate of IBT6A hydrochloride. IBT6A is an impurity of Ibrutinib. IBT6A can be used in synthesis of IBT6A Ibrutinib dimer and IBT6A adduct . Ibrutinib is a selective, irreversible Btk inhibitor with an IC₅₀ of 0.5 nM .

Cat. No.	Product Name

HY-L076

Drug-Induced Liver Injury (DILI) Compound Library

1,444 compounds

Drug-induced liver injury (DILI; also known as drug-induced hepatotoxicity) is caused by medications (prescription or OTC), herbal and dietary supplements (HDS), or other xenobiotics that result in abnormalities in liver tests or in hepatic dysfunction that cannot be explained by other causes. Drugs are an important cause of liver injury. Drug-induced hepatic injury is the most common reason cited for withdrawal of an approved drug.

DILI is thought to occur via several different mechanisms. Among these are direct impairment of the structural (e.g., mitochondrial dysfunction) and functional integrity of the liver; production of a metabolite that alters hepatocellular structure and function; production of a reactive drug metabolite that binds to hepatic proteins to produce new antigenic drug-protein adducts, which are targeted by hosts’ defenses (the hapten hypothesis); and initiation of a systemic hypersensitivity response (i.e., drug allergy) that damages the liver.

MCE Drug-induced Liver Injury (DILI) Compound Library contains a unique collection of 1,444 hepatotoxicity causing compounds and is a powerful tool to research DILI and other drug toxicities. This library can be used to understand the mechanisms of DILI, identify biomarkers for early DILI prediction, and allow timely recognition during drug development, thus finally achieving successful DILI prevention and assessment in the pre-marketing phase.

Cat. No.	Product Name	Type

HY-W273413

4-Hydrazino-7-nitro-benzofurazan hydrazine adduct NBD-H	Fluorescent Dyes/Probes
4-Hydrazino-7-nitro-benzofurazan hydrazine adduct is a fluorescent reagent for protein labeling.

HY-D0017

Dansyl chloride DNSCl	Protein Labeling
Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

HY-D2161A

AF 594 azide triethylamine	Fluorescent Dyes/Probes
AF 594 azide (triethylamine) is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide (triethylamine) forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne) .

HY-D2161

AF 594 azide

Fluorescent Dyes/Probes

AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

Cat. No.	Product Name	Type

HY-21623

Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct	Biochemical Assay Reagents
Dichloro[1,1'-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane adduct is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N0510A

Aristolochic acid sodium salt 5+ Cited Publications Aristolochic acid I sodium; TR 1736 sodium; Sodium aristolochate	Biochemical Assay Reagents
Aristolochic acid sodium salt (Sodium aristolate 1) is a component of some Chinese herbal medicines and is responsible for nephrotoxicity. It is a proagent that is activated by reduction of nitro groups to amines, resulting in the formation of cytotoxic DNA adducts.

HY-167538

sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct	Cell Assay Reagents
sn-Glycero-3-phosphocholine 1:1 cadmium chloride adduct is a biochemical reagent.

HY-W141077

1-Nitrosopyrrolidine	Gene Sequencing and Synthesis
1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.

HY-W141077R

1-Nitrosopyrrolidine (Standard)	Gene Sequencing and Synthesis
1-Nitrosopyrrolidine (Standard) is the analytical standard of 1-Nitrosopyrrolidine. This product is intended for research and analytical applications. 1-Nitrosopyrrolidine is a molecule that primarily interacts with DNA and proteins, leading to the formation of DNA adducts and protein adducts.

HY-155918

mPEG-CHO (MW 1000)

mPEG-Aldehyde (MW 1000)

Drug Delivery

mPEG-CHO (MW 1000) participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155915

mPEG-CHO (MW 350)

mPEG-Aldehyde (MW 350)

Drug Delivery

mPEG-CHO (MW 350) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155916

mPEG-CHO (MW 550)

mPEG-Aldehyde (MW 550)

Drug Delivery

mPEG-CHO (MW 550) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155917

mPEG-CHO (MW 750)

mPEG-Aldehyde (MW 750)

Drug Delivery

mPEG-CHO (MW 750) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155919

mPEG-CHO (MW 2000)

mPEG-Aldehyde (MW 2000)

Drug Delivery

mPEG-CHO (MW 2000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155920

mPEG-CHO (MW 3400)

mPEG-Aldehyde (MW 3400)

Drug Delivery

mPEG-CHO (MW 3400) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155921

mPEG-CHO (MW 5000)

mPEG-Aldehyde (MW 5000)

Drug Delivery

mPEG-CHO (MW 5000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155922

mPEG-CHO (MW 10000)

mPEG-Aldehyde (MW 10000)

Drug Delivery

mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155923

mPEG-CHO (MW 20000)

mPEG-Aldehyde (MW 20000)

Drug Delivery

mPEG-CHO (MW 20000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-32813

2-Amino-3-iodopyridine 3-Iodopyridin-2-amine	Biochemical Assay Reagents
2-Amino-3-iodopyridine (3-Iodopyridin-2-amine) can be coupled with formyl derivatives under a copper-catalyzed indole synthesis method, and then constructed azide analogs through copper-mediated conjugated adducts things. The nucleophilicity of 2-Amino-3-iodopyridine is lower than that of the corresponding aniline used in the synthesis of indole, a potential obstacle for future synthesis .

Cat. No.	Product Name	Target	Research Area

HY-139093

Paracetamol-cysteine	Peptides	Others
Paracetamol-cysteine is a Paracetamol-cysteine Paracetamol protein adduct (PPA) and is formed when paracetamol is oxidized to the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI) .

HY-116073

L-Penicillamine	Biochemical Assay Reagents	Metabolic Disease
L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct. L-Penicillamine is a metal chelating agent of intermediate strength .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-69014

2-O-Methylcytosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	DNA/RNA Synthesis Endogenous Metabolite
2-O-Methylcytosine, an O-alkylated analogue a DNA adduct, is the damaged nucleobase .

HY-N6828

Monocrotaline N-Oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Leguminosae Source classification Metabolic Disease Plants Crotalaria pallida Ait. Disease Research Fields	Others
Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-124489

2-Hydroxyestradiol 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	Endogenous Metabolite
2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .

HY-N0618

Sanggenon D	Flavanonols Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Inflammation/Immunology Disease Research Fields Morus alba Linn.	Lipase
Sanggenon D is a Diels-Alder-type adduct from Chinese crude agent root bark of mulberry ( Morus alba L.). Sanggenon D possesses antioxidant and inhibits Pancreatic lipase (PL) with the an IC50 of 0.77 μM.

HY-N0769

Isopimpinellin 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Coumarins Salvia prionitis Hance Plants Infection Microorganisms Phenylpropanoids Umbelliferae Inflammation/Immunology Disease Research Fields Cancer	DNA/RNA Synthesis Parasite
Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .

HY-N8022

Lucidin primeveroside Lucidin 3-O-β-primeveroside	Quinones Structural Classification Monophenols Classification of Application Fields Anthraquinones Source classification Rubiaceae Phenols Plants Disease Research Fields Rubia cordifolia L. Cancer	Biochemical Assay Reagents
Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .

HY-116832

Retrorsine N-oxide	Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Plants Compositae Baptisia australis (L.) R. Br. Disease Research Fields Cancer	Others
Retrorsine N-oxide, an N-oxide of pyrrolizidine alkaloid, is a carcinogen. Retrorsine N-oxide-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides .

HY-N6828R

Monocrotaline N-Oxide (Standard)	Alkaloids Structural Classification Pyrrole Alkaloids Leguminosae Source classification Crotalaria pallida Ait. Plants	Others
Monocrotaline N-Oxide (Standard) is the analytical standard of Monocrotaline N-Oxide. This product is intended for research and analytical applications. Monocrotaline N-Oxide, a monocrotaline metabolite, leads to DNA adduct formation in vivo .

HY-N3515

Multicaulisin	Infection Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Morus multicaulis Plants Moraceae Disease Research Fields Isoflavones	Bacterial
Multicaulisin, a new Diels-Alder type adduct from Morus multicaulis roots, potently effects against Staphylococcus aureus (MRSA) isolates. Multicaulisin is an antibacterial agent and has the potential for MRSA infections research .

HY-N0769R

Isopimpinellin (Standard)	Structural Classification Microorganisms Source classification Coumarins Phenylpropanoids Umbelliferae Plants	DNA/RNA Synthesis Parasite
Isopimpinellin (Standard) is the analytical standard of Isopimpinellin. This product is intended for research and analytical applications. Isopimpinellin, an orally active compound isolated from Glomerella cingulata. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect .

HY-113045

Aquacobalamin	Microorganisms Source classification	Endogenous Metabolite
Aquacobalamin is one of the major forms of vitamin B12 isolated from mammalian cells. Aquacobalamin accelerates the oxidation of azo-dye Orange II (HY-N1442) by HSO₅ ^- in aqueous solutions. Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant .

HY-113466

4-Hydroxynonenal Maximum Cited Publications 8 Publications Verification 4-HNE	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Endogenous metabolite Disease Research Fields Cancer	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite
4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria .

Cat. No.	Product Name	Chemical Structure

HY-124489S1

2-Hydroxyestradiol-d5
2-Hydroxyestradiol-d₅ is the deuterium labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[[1][3][4].

HY-113466S

4-Hydroxynonenal-d3

4-Hydroxynonenal-d₃ is the deuterium labeled 4-Hydroxynonenal. 4-Hydroxynonenal (4-HNE) is an α,β unsaturated hydroxyalkenal and an oxidative/nitrosative stress biomarker. 4-Hydroxynonenal is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2). 4-Hydroxynonenal can modulate a number of signaling processes mainly through forming covalent adducts with nucleophilic functional groups in proteins, nucleic acids, and membrane lipids. 4-Hydroxynonenal plays an important role in cancer through mitochondria[1][2][3].

HY-124489S

2-Hydroxyestradiol-13C6
2-Hydroxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Hydroxyestradiol. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity[1][3].

HY-W010482S

3-Ethylaniline-d5
3-Ethylaniline-d₅ is the deuterium labeled 3-Ethylaniline (HY-W010482). 3-Ethylaniline is metabolized in vivo to electrophilic intermediates that covalently bind to DNA and that adducts are formed in the DNA of bladder. 3-Ethylaniline can be used for the research of bladder cancer[1][2].

HY-W016433S

2-Aminofluorene-13C
2-Aminofluorene- ¹³C is the ¹³C labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].

HY-W016433S1

2-Aminofluorene-d11
2-Aminofluorene-d₁₁ is the deuterium labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].

HY-128463S

N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d₁₄ is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

Cat. No.	Product Name		Classification

HY-W192446

Nicotinoyl azide		Azide
Nicotinoyl azide is capable of forming high energy intermediates known to form C-8 adducts with adenosine and guanosine . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.

HY-D2161

AF 594 azide		Azide
AF 594 azide is an azide derivative of the red fluorescent dye AF 594, which has high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 azide forms stable adducts by reaction of the azide group with alkynyl derivatives (terminal alkynes and cyclooctyne). It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups .

Cat. No.	Product Name		Classification

HY-154406

2′-Deoxy-N-methylguanosine		Nucleosides and their Analogs
2’-Deoxy-N2-methylguanosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-155918

mPEG-CHO (MW 1000) mPEG-Aldehyde (MW 1000)		Polymers
mPEG-CHO (MW 1000) participates in the formation of a three-dimensional porous scaffold that carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155915

mPEG-CHO (MW 350) mPEG-Aldehyde (MW 350)		Polymers
mPEG-CHO (MW 350) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155916

mPEG-CHO (MW 550) mPEG-Aldehyde (MW 550)		Polymers
mPEG-CHO (MW 550) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155917

mPEG-CHO (MW 750) mPEG-Aldehyde (MW 750)		Polymers
mPEG-CHO (MW 750) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155919

mPEG-CHO (MW 2000) mPEG-Aldehyde (MW 2000)		Polymers
mPEG-CHO (MW 2000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155920

mPEG-CHO (MW 3400) mPEG-Aldehyde (MW 3400)		Polymers
mPEG-CHO (MW 3400) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155921

mPEG-CHO (MW 5000) mPEG-Aldehyde (MW 5000)		Polymers
mPEG-CHO (MW 5000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155922

mPEG-CHO (MW 10000) mPEG-Aldehyde (MW 10000)		Polymers
mPEG-CHO (MW 10000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

HY-155923

mPEG-CHO (MW 20000) mPEG-Aldehyde (MW 20000)		Polymers
mPEG-CHO (MW 20000) participates in the formation of a three-dimensional porous scaffold which carries active substances to form a delivery vehicle. The -CHO functional group interacts with the -NH2 functional group of the chitosan chain to form a glutaraldehyde-type adduct to functionalize mPEG. This functionalization and cross-linking can affect the rigidity of the delivery system, allowing slow release of the cross-linked conjugate system.

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