6-O-Methyldeoxyguanosine (Synonyms: O6-Methyl-2′-deoxyguanosine)

Name: 6-O-Methyldeoxyguanosine
Brand: MedChemExpress
SKU: HY-W347492
Rating: 4.5 (1 reviews)

Cat. No.: HY-W347492 Purity: 99.34%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

O6-Methyldeoxy guanosine; DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

6-O-Methyldeoxyguanosine Chemical Structure

CAS No. : 964-21-6

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 240	In-stock	Estimated Time of Arrival: April 11
Solution
10 mM * 1 mL in DMSO	USD 253	In-stock	Estimated Time of Arrival: April 11
Solid
5 mg	USD 230	In-stock	Estimated Time of Arrival: April 11
10 mg	USD 390	In-stock	Estimated Time of Arrival: April 11
25 mg	USD 780	In-stock	Estimated Time of Arrival: April 11
50 mg	USD 1250	In-stock	Estimated Time of Arrival: April 11
100 mg	USD 1950	In-stock	Estimated Time of Arrival: April 11
200 mg		Get quote
500 mg		Get quote

Get it by April 15 for select sizes. Order within 3 hrs 33 mins.

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

281.27

Formula

C₁₁H₁₅N₅O₄

CAS No.

964-21-6

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1C[C@H](N2C=NC3=C2N=C(N)N=C3OC)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (355.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5553 mL	17.7765 mL	35.5530 mL
5 mM	0.7111 mL	3.5553 mL	7.1106 mL
10 mM	0.3555 mL	1.7777 mL	3.5553 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 99.34%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (250 KB) RP-HPLC (460 KB) MS (95 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5553 mL	17.7765 mL	35.5530 mL	88.8826 mL
	5 mM	0.7111 mL	3.5553 mL	7.1106 mL	17.7765 mL
	10 mM	0.3555 mL	1.7777 mL	3.5553 mL	8.8883 mL
	15 mM	0.2370 mL	1.1851 mL	2.3702 mL	5.9255 mL
	20 mM	0.1778 mL	0.8888 mL	1.7777 mL	4.4441 mL
	25 mM	0.1422 mL	0.7111 mL	1.4221 mL	3.5553 mL
	30 mM	0.1185 mL	0.5926 mL	1.1851 mL	2.9628 mL
	40 mM	0.0889 mL	0.4444 mL	0.8888 mL	2.2221 mL
	50 mM	0.0711 mL	0.3555 mL	0.7111 mL	1.7777 mL
	60 mM	0.0593 mL	0.2963 mL	0.5926 mL	1.4814 mL
	80 mM	0.0444 mL	0.2222 mL	0.4444 mL	1.1110 mL
	100 mM	0.0356 mL	0.1778 mL	0.3555 mL	0.8888 mL

6-O-Methyldeoxyguanosine Related Classifications

Keywords:

6-O-Methyldeoxyguanosine964-21-6O6-Methyl-2′-deoxyguanosineNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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6-O-Methyldeoxyguanosine (Synonyms: O6-Methyl-2′-deoxyguanosine)

Customer Review

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•Related Screening Libraries:

Biological Activity

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References

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Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

6-O-Methyldeoxyguanosine Related Classifications

Keywords:

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