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airway smooth muscle contraction

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1640
    Ethacrynic acid
    4 Publications Verification

    Etacrynic acid

    		 Glutathione S-transferase NF-κB Calcium Channel NO Synthase Cardiovascular Disease Inflammation/Immunology Cancer
    Ethacrynic acid has anti-inflammatory and anticancer activity. Ethacrynic acid is an orally active diuretic. Ethacrynic acid is an inhibitor of glutathione S-transferase (GSTs) and Wnt signaling pathways. Ethacrynic acid is a radiosensitizer. Ethacrynic acid can inhibit airway smooth muscle (ASM) contraction in mice. Ethacrynic acid can increase the outflow of aqueous humor from the eye for the study of glaucoma .
    Ethacrynic acid
  • HY-134092
    N-Methyl Leukotriene C4

    N-Methyl-LTC4

    		 Leukotriene Receptor Inflammation/Immunology
    N-Methyl Leukotriene C4 stimulates contraction of airway smooth muscle in animals, with efficacy varying by tissue and species. For example, it can stimulate the lungs of bullfrogs to contract .
    N-Methyl Leukotriene C4
  • HY-115314
    Mequitamium iodide

    LG 30435

    		 Histamine Receptor Inflammation/Immunology
    Mequitamium iodide (LG 30435) is an antihistamine drug with antiallergic and bronchodilatory activity. Mequitamium iodide can effectively antagonize airway contraction and inflammatory responses induced by histamine and antigens. Mequitamium iodide has nanomolar affinity for the H1 and smooth muscle receptors of histamine and mequitin. Mequitamium iodide, when administered in aerosol form, significantly inhibits histamine- and antigen-induced increases in airway pressure in allergic mice. Mequitamium iodide reduces antigen-induced eosinophil accumulation in the airways. Mequitamium iodide also exhibits inhibitory effects on PAF-induced platelet aggregation and bronchoconstriction, and can be used in the study of allergic diseases such as rhinitis and asthma .
    Mequitamium iodide

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