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Results for "

anti-osteoclastogenic

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

5

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147369
    NFATc1-IN-1
    2 Publications Verification

    		 Nuclear Factor of activated T Cells (NFAT) Others
    NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research .
    NFATc1-IN-1
  • HY-N9199
    6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid

    		Others Others
    6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid (Compound 14) is an osteoclast inhibitor with anti-osteoclastogenic activity. 6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid can be obtained from Eriobotrya japonica leaves. 6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid can be used in osteoporosis research .
    6β,19-Dihydroxyurs-12-en-3-oxo-28-oic acid
  • HY-N3071
    Picrasidine I

    		Apoptosis Reactive Oxygen Species Inflammation/Immunology
    Picrasidine I is an anti-inflammatory and anti-osteoclastogenic dimeric alkaloid that can be isolated from Picrasma quassioides. Picrasidine I inducs cell cycle arrest, and triggers cell apoptosis by downregulats ERK and Akt pathways. Picrasidine I inhibits the activation of MAPKs, NF-κB and ROS generation, and suppresses the expression of c-Fos and NFATc1 .
    Picrasidine I
  • HY-N11492
    7(R)-7,8-Dihydrosinomenine

    		Others Metabolic Disease
    7(R)-7,8-Dihydrosinomenine, a isoquinoline alkaloid that can be isolated from Sinomenium acutum (Menispermaceae), possesses anti-osteoclastogenic effect .
    7(R)-7,8-Dihydrosinomenine
  • HY-N9602
    6,7,4'-Trihydroxyflavanone

    		Others Inflammation/Immunology
    6,7,4'-Trihydroxyflavanone is a compound with multiple pharmacological activities, including anti-rheumatic, anti-ischemic, anti-inflammatory, anti-osteoclastogenic and protective T-cells from METH-induced deactivation. 6,7,4'-Trihydroxyflavanone has shown potential protective effects in neurotoxicity studies and can be used to inhibit patients with neurodegenerative diseases caused by METH. 6,7,4'-Trihydroxyflavanone inhibits METH-induced neurotoxicity by upregulating the Nrf2/HO-1 and PI3K/Akt/mTOR signaling pathways. 6,7,4'-Trihydroxyflavanone can also induce Nrf2 nuclear translocation and HO-1 expression, further enhancing its protective effect on neuronal cells .
    6,7,4'-Trihydroxyflavanone
  • HY-N11491
    8-Demethoxycephatonine

    		Others Others
    8-Demethoxycephatonine is an isoquinoline alkaloid, that can be isolated from Sinomenium acutum (Menispermaceae) .
    8-Demethoxycephatonine

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