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antileishmanial

" in MedChemExpress (MCE) Product Catalog:

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-162498

Antileishmanial agent-29	Parasite	Infection
Antileishmanial agent-29 (Compound 110) is an orally active antileishmanial agent. Antileishmanial agent-29 (p.o., 40, 60 mg/kg, 10 days) protects mice from leishmania infection .

HY-155301

Antileishmanial agent-24	Parasite	Infection
Antileishmanial agent-24 (compound 33) is an antileishmanial agent with an IC₅₀ of 5.39 μM against amastigote .

HY-138812

Antileishmanial agent-28	Parasite	Infection Inflammation/Immunology
Antileishmanial agent-28 (Compd 12) is an antileishmanial agent, with EC₅₀ values of 1.5 μM (L.donovani), 13 μM (L.amazonensis) and 18 μM (J774A.1), respectively .

HY-156427

Antileishmanial agent-25	Parasite	Infection
Antileishmanial agent-25 (compound 24) is selective *antileishmanial* activity on intracellular amastigotes, with the IC₅₀ of 6.63 μM .

HY-155549

Antileishmanial agent-20	Parasite	Infection
Antileishmanial agent-20 is selective towards Leishmania parasite. Antileishmanial agent-20 has IC₅₀ value of 2.8 μM and 0.2 μM for L. infantum and L. braziliensis, respectively. Antileishmanial agent-20 can be used for parasites research .

HY-149834

Antileishmanial agent-18	Parasite	Infection
Antileishmanial agent-18 (Compound 1e) is an antileishmanial agent. Antileishmanial agent-18 effectively inhibits growth of L. donovani promastigotes. Antileishmanial agent-18 is safe for host cells .

HY-149956

Antileishmanial agent-15	Parasite	Infection
Antileishmanial agent-15 (compound 13c) is a potent antileishmanial agent. Antileishmanial agent-15 shows antileishmanial and cytotoxic activity against L. major promastigotes and amastigotes, with IC₅₀ values of 0.78 and 0.99 μM, respectively .

HY-146744

Antileishmanial agent-4	Parasite	Infection
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent .

HY-149958

Antileishmanial agent-17	Parasite	Infection
Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC₅₀ <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC₅₀ value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.

HY-163457

Antileishmanial agent-27	Aminoacyl-tRNA Synthetase Parasite	Infection
Antileishmanial agent-27 (compound 7j) is a benzothiazolo-coumarin derivative. Antileishmanial agent-27 is a competitive inhibitor of arginyl-tRNA synthetases (ArgRSs). Antileishmanial agent-27 shows selectivity toward ArgRS of Leishmania donovani (LdArgRS) than its human counterpart (HsArgRS), with IC₅₀ values of 1.2 and 19 μM, respectively. Antileishmanial agent-27 possesses high pharmacokinetic properties .

HY-146745

Antileishmanial agent-5	Parasite	Inflammation/Immunology
Antileishmanial agent-4 is a ribonucleoside analogue and acts as an antileishmanial agent. Antileishmanial agent-4 is against L.infantum and T.cruzi with EC₅₀ values of 0.68 μM and 0.83 μM, respectively .

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-147535

Antileishmanial agent-7	Parasite	Infection
Antileishmanial agent-7 (compound 23) is a potent antileishmanial agent. Antileishmanial agent-7 shows antileishmanial activity against Leishmania donovani and L-6, with IC₅₀ values of 6.89 and 259 μM, respectively .

HY-147534

Antileishmanial agent-6	Parasite	Infection
Antileishmanial agent-6 (compound 8m) is a potent antileishmanial agent. Antileishmanial agent-6 shows antileishmanial and cytotoxic activity against Leishmania donovani and L-6, with IC₅₀ values of 0.54 and 10.2 μM, respectively .

HY-147537

Antileishmanial agent-9	Parasite	Infection
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC₅₀ = 40.1 μM) .

HY-147536

Antileishmanial agent-8	Parasite	Infection
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC₅₀ value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC₅₀=73.9 μM) .

HY-155845

Antileishmanial agent-21	Parasite	Infection
Antileishmanial agent-21 (compound 4e) is an antileishmanial agent that targets the Leishmania pteridine reductase 1 (Lm-PTR1). Antileishmanial agent-21 has an anti-folate mechanism, and folic acid and leucovorin can reverse the anti-leishmanial activity of Antileishmanial agent-21. Antileishmanial agent-21 inhibits the Chloroquine (HY-17589A)-resistant strain of Plasmodium falciparum (RKL9) with an IC₅₀ of 0.0198-0.096 μM .

HY-151935

Antileishmanial agent-13	Parasite	Infection
Antileishmanial agent-13 is a quinoline-isatin hybrid, acts as an antileishmanial agent against L. Major Leishmania strain. Antileishmanial agent-13 acquires the antileishmanial activity via the anti-folate mechanism. Antileishmanial agent-13 has potent inhibition against both promastigote and amastigote forms with IC₅₀s of 0.604 μM and 0.508 μM, respectively .

HY-155846

Antileishmanial agent-22	Parasite Bacterial	Infection
Antileishmanial agent-22 (compound 15b) is a parasite inhibitor and an antibacterial agent, with antileishmanial, antimalarial, and anti-tubercular activities. Antileishmanial agent-22 inhibits leishmanial (IC₅₀=0.408 μM) based on antifolate mechanism. And, Antileishmanial agent-22 inhibits Folic acid and Folinic acid at 100 μM with inhibitory rates of 88% and 94%, respectively. Antileishmanial agent-22 inhibits P. berghei in vivo and in vitro, with 96.67% suppression under 48.4 μM/kg/day and 0.038 μM (IC₅₀), respectively. Moreover, Antileishmanial agent-22 inhibits M. tuberculosis with MIC of 28.44 μM .

HY-147857

Antileishmanial agent-12	Parasite	Infection
Antileishmanial agent-12 (compound 5a) is a potent anti-leishmanial agent. Antileishmanial agent-12 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC₅₀ values of 14.9, 21.3 and 9.3 μM, respectively .

HY-132905

Antileishmanial agent-2	Parasite	Infection
Antileishmanial agent-2 shows submicromolar antileishmanial activity (IC₅₀ = 0.29 μM) and a very high selectivity index with respect to mammalian cells.

HY-147856

Antileishmanial agent-11	Parasite	Infection
Antileishmanial agent-11 (compound 4d) is a potent anti-leishmanial agent. Antileishmanial agent-11 shows antiprotozoal activity against Leishmania brazilensis, Leishmania infantum, and T. cruzi, with IC₅₀ values of 28.3, 24.8 and 13.0 μM, respectively .

HY-149957

Antileishmanial agent-16	Parasite	Infection
Antileishmanial agent-16 (compound 14c) is an anti-Leishmania agent. Antileishmanial agent-16 has superior anti-Leishmania major promastigotes activity (IC₅₀ = 0.59 µM) and anti-Leishmania major amastigotes activity (IC₅₀ = 0.81 µM). Antileishmanial agent-16 has good safety to mammalian cells (VERO cells) .

HY-155207

Antileishmanial agent-23	Parasite	Infection
Antileishmanial agent-23 (compound G1/9) is a potent and selective trypanothione reductase (TR) inhibitor, with an IC₅₀ of 2.24 ± 0.52 μM. Antileishmanial agent-23 inhibits the growth of Leishmania, Trypanosoma cruzi, and Trypanosoma brucei .

HY-147766

Antileishmanial agent-10	Parasite	Infection
Antileishmanial agent-10 (Compound 7h) is an antiprotozoal agent .

HY-149093

Antileishmanial agent-14	Parasite	Infection
Antileishmanial agent-14 is a sulfuretin analog with potential activity against the parasite Leishmania donovani promastigotes (IC₅₀=4.1 μM). Antileishmanial agent-14 also inhibits infection by L. donovani amastigotes (IC₅₀=11.1 μM) .

HY-144700

Antileishmanial agent-3	Parasite	Infection
Antileishmanial agent-3 (Compound 13) is a promising growth inhibitor of Leishmania major .

HY-161325

Antileishmanial agent-26	Parasite	Infection
Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC₅₀ value against Leishmania donovani is 5.67 μM, and its CC₅₀ value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases .

HY-115725

Antileishmanial agent-1	Parasite	Infection
Antileishmanial agent-1 exhibits the activity against L. amazonensis promastigotes (IC₅₀ = 15.52 μM) and intracellular amastigotes (IC₅₀ = 4.10 μM).

HY-162833

Antileishmanial agent-30	Parasite	Infection
Antileishmanial agent-30 (compound 17k) is a potent inhibitor of leishmania, with the IC₅₀, CC₅₀, and SI of 0.2 μM, >100 μM and >500 for L. donovani .

HY-N7985

Pendulone	Parasite Bacterial	Infection Cancer
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-134467

Phylloflavan	Parasite	Infection
Phylloflavan is an antileishmanial agent with an intracellular EC₅₀ of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL) .

HY-N1077

Vomifoliol	Cholinesterase (ChE) Endogenous Metabolite	Others
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate *antileishmanial* activity .

HY-19688B

Sitamaquine tosylate WR 6026 tosylate	Parasite	Infection
Sitamaquine (WR 6026) tosylate, an orally active 8-aminoquinoline analog, is an antileishmanial agent. Sitamaquine is a lipophilic weak base that rapidly accumulates in acidic compartments of Leishmania spp., mainly in acidocalcisomes .

HY-W019829

Polyphyllin C	Tyrosinase Parasite	Infection
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-156464

Topoisomerase I inhibitor 10	Topoisomerase	Infection
Topoisomerase I inhibitor 10 (compound 13) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 10 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 27.91 μM .

HY-131300

Colchicoside	Parasite	Infection
Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .

HY-156462

Topoisomerase I inhibitor 9	Topoisomerase	Infection
Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC₅₀ of 34.81μM .

HY-W077028

N-(2-Hydroxypropyl)methacrylamide	Others	Others
N-(2-Hydroxypropyl)methacrylamide is used to synthesize copolymers for the targeted delivery of antileishmanial agents in Visceral leishmaniasis (VL) .

HY-W012634S

Benzothiazole-d4	Isotope-Labeled Compounds	Cancer
Benzothiazole-d₄ is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

HY-W012634

Benzothiazole	Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-121368

Mahanine	Parasite	Infection Inflammation/Immunology Cancer
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

HY-N8471

Niazinin	Parasite SARS-CoV	Infection Inflammation/Immunology
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-W012634R

Benzothiazole (Standard)	Bacterial	Infection Metabolic Disease Inflammation/Immunology Cancer
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .

HY-N1453

Hypocrellin B 1 Publications Verification	Apoptosis Fungal Parasite	Infection Cancer
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .

HY-N6015

Bacopasaponin C	Parasite	Cancer
Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities .

HY-N6816

Ludaconitine	Parasite	Infection
Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL .

HY-127160

Benzoxonium chloride	Parasite Bacterial	Infection
Benzoxonium chloride is an anti-leishmanial agent. Benzoxonium chloride inhibits bacteria, certain protozoa, yeasts and non-spore forming organisms .

HY-W159102

8CN	Parasite	Infection
8CN, a 2-amino-thiophene derivative, has anti-leishmanial activity. 8CN can be used in research of Leishmaniasis .

HY-101011

Naloxonazine dihydrochloride	Opioid Receptor	Infection Neurological Disease
Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC₅₀ of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity .

Cat. No.	Product Name	Target	Research Area

HY-P2310A

Defensin HNP-1 human TFA	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human TFA is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human TFA exhibits broad antimicrobial and anti-leishmanial activities .

HY-P2310

Defensin HNP-1 human	Bacterial Parasite	Infection Cardiovascular Disease
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities .

HY-P1957

Dihydrocyclosporin A	Parasite	Infection
Dihydrocyclosporin A is a derivative of Cyclosporine A (HY-B0579). Dihydrocyclosporin A significantly inhibites promastigotes and intracellular amastigotes. Dihydrocyclosporin A is highly cytotoxic .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1077

Vomifoliol	Structural Classification Natural Products Classification of Application Fields Source classification Plants Endogenous metabolite Agricultural Research Human Gut Microbiota Metabolites Microorganisms other families Other Diseases Abscisic acid Phytohormone Disease Research Fields	Cholinesterase (ChE) Endogenous Metabolite
Vomifoliol, a compound related to abscisie acid (ABA), has a modified 2,4-pentadiene side chain and has activity equal to that displayed by ABA. Vomifoliol exhibits antiacetylcholinesterase activity and displays moderate *antileishmanial* activity .

HY-131300

Colchicoside	Colchicaceae Source classification Gloriosa superbaL. Plants	Parasite
Colchicoside is a bioactive tropolone alkaloid with anti-leishmanial and anti-leishmanial?activities .

HY-W012634

Benzothiazole	Microorganisms Source classification	Bacterial
Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent ^[1][2][3][4].

HY-121368

Mahanine	Structural Classification Classification of Application Fields Source classification Rutaceae Plants Indole Alkaloids Infection Alkaloids Monophenols Murraya koenigii (L.) Spreng Phenols Inflammation/Immunology Disease Research Fields	Parasite
Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research.

HY-N8471

Niazinin	Structural Classification Natural Products Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	Parasite SARS-CoV
Niazinin is a thiocarbamate glycoside with antileishmanial activities, with an IC₅₀ value of 5.25 μM. Niazinin also shows a binding affinity with the target protein 3CL protease. Niazinin has promising leishmanicidal, anti-inflammatory and anti-pyretic activity .

HY-N1453

Hypocrellin B 1 Publications Verification	Infection Structural Classification Microorganisms other families Classification of Application Fields Source classification Phenols Polyphenols Pigments Plants Disease Research Fields Food Research	Apoptosis Fungal Parasite
Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities .

HY-N7985

Pendulone	Infection Quinones Monophenols other families Classification of Application Fields Source classification Phenols Benzene Quinones Plants Disease Research Fields	Parasite Bacterial
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC₅₀ of 7.0 µM. Pendulone also has antileishmanial, antibacterial and anticancer activity .

HY-134467

Phylloflavan	Structural Classification other families Phyllocladus alpinus Source classification Phenols Polyphenols Plants	Parasite
Phylloflavan is an antileishmanial agent with an intracellular EC₅₀ of 3.2 nM in RAW 264.7 cells. Phylloflavan also inhibits the cytopathic effect of encephalomyocarditis virus on L929 fibroblast cells (38 U/mL) .

HY-W019829

Polyphyllin C	Infection other families Classification of Application Fields Source classification Plants Disease Research Fields Steroids	Tyrosinase Parasite
Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC₅₀=36.87 µM) activities against the tyrosinase and moderate (IC₅₀=1.59 µg/mL) antileishmanial activities .

HY-W012634R

Benzothiazole (Standard)	Microorganisms Source classification	Bacterial
Benzothiazole (Standard) is the analytical standard of Benzothiazole. This product is intended for research and analytical applications. Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral. Furthermore, Benzothiazole nucleus can function as an efficacious β-amyloid imaging agent .

HY-N6015

Bacopasaponin C	Triterpenes Classification of Application Fields Terpenoids Source classification Scrophulariaceae Plants Disease Research Fields Bacopa monnieri (Linn.) Wettst. Cancer	Parasite
Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities .

HY-N6816

Ludaconitine	Infection Classification of Application Fields Terpenoids Source classification Ranunculaceae Diterpenoids Aconitum carmichaeli Debx. Plants Disease Research Fields	Parasite
Ludaconitine, isolated from Aconitum spicatum (Bruhl) Stapf, exhibits antileishmanial activity with an IC₅₀ of 36.10 μg/mL .

HY-B0221A

Amphotericin B trihydrate	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Inflammation/Immunology Disease Research Fields	Antibiotic Fungal Bacterial Parasite
Amphotericin B trihydrate, a polyene antibiotic, is first isolated from fermenter cultures of Streptomyces nodosus. Amphotericin B trihydrate also possesses antileishmanial activity .

HY-125648

Euphorbadienol alpha-Euphorbol	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Euphorbia wallichii Euphorbiaceae Plants Disease Research Fields	Parasite
Euphorbadienol (alpha-Euphorbol), a triterpenic compound, isolated from the latex of Euphorbia resinifera. The derivatives of Euphorbadienol can be used as elicitors of disease resistance, and has antileishmanial and antitrypanosomal activity .

HY-75247

Coumaran 2 Publications Verification 2,3-Dihydrobenzofuran	Structural Classification Natural Products Verbenaceae Source classification Plants Endogenous metabolite Lantana camaraLinn.	Cholinesterase (ChE) Endogenous Metabolite Parasite
Coumaran (2,3-Dihydrobenzofuran) is an AChE inhibitor with antileishmanial activity. Coumaran may acquire antiparasitic capabilities through activation of macrophages and exert immunomodulatory activity. Coumaran can be used as a biopesticide. .

HY-N6015R

Bacopasaponin C (Standard)	Triterpenes Structural Classification Terpenoids Source classification Scrophulariaceae Plants Bacopa monnieri (Linn.) Wettst.	Parasite
Bacopasaponin C (Standard) is the analytical standard of Bacopasaponin C. This product is intended for research and analytical applications. Bacopasaponin C is an indigenous glycoside isolated from Bacopa monniera, with antitumor and anti-leishmanial activities .

HY-N2926

β-Carboline-1-propionic acid	Structural Classification Alkaloids Simaroubaceae Ailanthus altissima (Mill.) Swingle Pyrrole Alkaloids Source classification Plants	Parasite
β-Carboline-1-propionic acid is a alkaloid which can be extracted from Ailanthus altissima. β-Carboline-1-propionic acid can be used as an antileishmanial agent .

HY-N7906

Myricetin 3-O-glucoside Myricetin 3-β-D-glucopyranoside	Structural Classification Flavonoids Microorganisms Leguminosae Clitoria ternatea Linn. Source classification Plants Isoflavones	Bacterial Parasite Antibiotic
Myricetin 3-O-glucoside (Myricetin 3-β-D-glucopyranoside) is a flavonol from Tibouchina paratropica. Myricetin 3-O-glucoside exhibits anti-Leishmanial, anti-inflammatory and antimicrobial activities .

HY-N7489

β-Hederin	Triterpenes Hedera nepalensis K. Koch var. sinensis (Tobl.) Rehd. Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Inflammation/Immunology Araliaceae	Parasite
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses *antileishmanial* activity. β-Hederin exhibits IC₅₀ values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively .

HY-N8181

1,3-Linolein-2-Olein	Infection Structural Classification Natural Products Classification of Application Fields Source classification Campanulaceae Plants Codonopsis thalictrifoliaWall. Disease Research Fields	Parasite
1,3-Linolein-2-Olein, a triglyceride, is an antileishmanial agent. 1,3-Linolein-2-Olein inhibits promatigotes of the parasite (IC₅₀=0.079 ug/ml) and inhibits the growth of amastigotes (IC₅₀= 40.03 ug/ml) .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Structural Classification Source classification Phenols Polyphenols Hypoxis angustifolia Lam. Plants Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, *antileishmanial, hyaluronidase* inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-W015818

2-Benzoxazolinone 1 Publications Verification 2-Benzoxazolone; 1,3-Benzoxazol-2(3H)-one; 2-Hydroxybenzoxazole	Infection Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Gramineae Source classification Secale cereale Plants Disease Research Fields	Parasite
2-Benzoxazolinone is an *anti-leishmanial* agent with an LC₅₀ of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent .

HY-N0397

Harpagide	Structural Classification Iridoids Classification of Application Fields Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants Inflammation/Immunology Disease Research Fields	Parasite
Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (*T.b. rhodesiense) with an IC₅₀* of 21 μg/mL. Harpagide exerts significant antileishmanial activity against *L. donovani* with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-N0397R

Harpagide (Standard)	Structural Classification Iridoids Scrophularia ningpoensis Hemsl. Terpenoids Source classification Scrophulariaceae Plants	Parasite
Harpagide (Standard) is the analytical standard of Harpagide. This product is intended for research and analytical applications. Harpagide is a class of iridoid glycoside isolated from Scrophularia ningpoensis and has antiparasitic activity, which exhibits good in vitro trypanocidal activities against African trypanosomes (T.b. rhodesiense) with an IC₅₀ of 21 μg/mL. Harpagide exerts significant antileishmanial activity against L. donovani with an IC₅₀ value of 2.0 μg/mL. Harpagide also possess significant anti-inflammatory activities .

HY-W015818R

2-Benzoxazolinone (Standard)	Alkaloids Structural Classification Other Alkaloids Gramineae Source classification Secale cereale Plants	Parasite
2-Benzoxazolinone (Standard) is the analytical standard of 2-Benzoxazolinone. This product is intended for research and analytical applications. 2-Benzoxazolinone is an anti-leishmanial agent with an LC50 of 40 μg/mL against L. donovani . A building block in chemical synthesis. 1,3-Benzoxazol-2(3H)-one derivatives have antimicrobial activity against a selection of Gram-positive, Gram-negative bacteria and yeasts . Derivatives as anti-quorum sensing agent[4].

HY-N2894

Piperolactam A	Structural Classification Alkaloids Piper betle L. Source classification Piperaceae Plants	Parasite
Piperolactam A is a natural product that can be isolated from root of Piper betle. Piperolactam A exhibits promising leishmanicidal action against wild type and drug resistant strains of Leishmania donovani .

Cat. No.	Product Name	Chemical Structure

HY-B0219S

Allopurinol-d2
Allopurinol-d₂ is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].

HY-W012634S

Benzothiazole-d4
Benzothiazole-d₄ is a deuterium labeled Benzothiazole (HY-W012634). Benzothiazole is a natural occurring heterocyclic nuclei. Benzothiazole nucleus possesses a number of biological activities such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, antileishmanial, and antiviral .

Cat. No.	Product Name		Classification

HY-168262

Antitrypanosomal agent 22		Alkynes
Antitrypanosomal agent 22 (compound 13) is a nitrothienylazine compound with trypanosomaticidal efficacy. Antitrypanosomal agent 22 shows leishmanicidal and trypanocidal with in vitro submicromolar activities, and devoid of toxicity on mammalian cells are uncovered .

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