Nyasol  (Synonyms: (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol)

Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells^[1][2].

252.31

C₁₇H₁₆O₂

96895-25-9

C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14.  [Content Brief]

  [2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8.  [Content Brief]

  [3]. Lee HJ, et al. (-)-Nyasol, isolated from Anemarrhena asphodeloides suppresses neuroinflammatory response through the inhibition of I-κBα degradation in LPS-stimulated BV-2 microglial cells. J Enzyme Inhib Med Chem. 2013 Oct;28(5):954-9.  [Content Brief]