2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. Naloxonazine dihydrochloride

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity.

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Naloxonazine dihydrochloride Chemical Structure

Naloxonazine dihydrochloride Chemical Structure

CAS No. : 880759-65-9

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Based on 1 publication(s) in Google Scholar

Other Forms of Naloxonazine dihydrochloride:

Naloxonazine dihydrochloride Related Antibodies

Top Publications Citing Use of Products

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Naloxonazine dihydrochloride is a specific μ-opioid receptor antagonist with an IC50 of 5.4 nM. Naloxonazine dihydrochloride also shows anti-leishmanial activity[1][2][3].

IC50 & Target

μ Opioid Receptor/MOR

5.4 nM (IC50)

In Vitro

Naloxonazine is relatively stable in solution[2].
Naloxonazine (72 h) is active against the intracellular amastigote stage of Leishmania donovani with a half maximal inhibitory concentration (GI50) of 3.45 μM[3].
Naloxonazine (10 μM; 0-72 h) is active at early stages of Leishmania donovani infection[3].
Naloxonazine affects acidic compartments of the host cell which in turn limit L. donovani intracellular growth[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Naloxonazine dihydrochloride Related Antibodies
In Vivo

Naloxonazine (20 mg/kg; i.p.; once) attenuates the increment of locomotor activity induced by acute methamphetamine in mice[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice, methamphetamine (METH)-induced locomotor activity model[1]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection, once, 60 min before injecting saline (i.p.) or METH (1 mg/kg, i.p.)
Result: Significantly attenuated the acute METH-induced increase in locomotor activity and phosphor-Thr75 DARPP-32 levels.
Molecular Weight

723.69

Formula

C38H44Cl2N4O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@]([C@@]1([H])CC2=CC=C3O)(CC/4)[C@@]5(CCN1CC=C)C2=C3O[C@@]5([H])C4=N\N=C(CC[C@]67O)\[C@@]8([H])[C@]6(CCN(CC=C)[C@]7([H])CC9=CC=C%10O)C9=C%10O8.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 25 mg/mL (34.55 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3818 mL 6.9090 mL 13.8181 mL
5 mM 0.2764 mL 1.3818 mL 2.7636 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 98.1%

COA (258 KB) Elemental Analysis Report (116 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3818 mL 6.9090 mL 13.8181 mL 34.5452 mL
5 mM 0.2764 mL 1.3818 mL 2.7636 mL 6.9090 mL
10 mM 0.1382 mL 0.6909 mL 1.3818 mL 3.4545 mL
15 mM 0.0921 mL 0.4606 mL 0.9212 mL 2.3030 mL
20 mM 0.0691 mL 0.3455 mL 0.6909 mL 1.7273 mL
25 mM 0.0553 mL 0.2764 mL 0.5527 mL 1.3818 mL
30 mM 0.0461 mL 0.2303 mL 0.4606 mL 1.1515 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Naloxonazine dihydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Naloxonazine880759-65-9Opioid Receptoranti-leishmanialLeishmania donovanirelatively stableInhibitorinhibitorinhibit

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