2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 9

Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM.

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Topoisomerase I inhibitor 9 Chemical Structure

Topoisomerase I inhibitor 9 Chemical Structure

CAS No. : 1228150-86-4

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Description

Topoisomerase I inhibitor 9 (compound 3d) is a leishmanial topoisomerase IB inhibitor. Topoisomerase I inhibitor 9 has antileishmanial activity against L. donovani promastigotes, with the IC50 of 34.81μM[1].

IC50 & Target

34.81 μM[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
4.5 μM
Compound: 2m
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
10.1007/s00044-013-0764-4
HeLa IC50
2.7 μM
Compound: 2m
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
10.1007/s00044-013-0764-4
PC-3 IC50
3.9 μM
Compound: 2m
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells after 48 hrs by MTT assay
10.1007/s00044-013-0764-4
Molecular Weight

498.19

Formula

C23H15Br2FN2
CAS No.
SMILES

FC1=CC=C(C(C2=CNC3=C2C=C(Br)C=C3)C4=CNC5=C4C=C(Br)C=C5)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase I inhibitor 9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 91228150-86-4Topoisomerase I inhibitor9Topoisomerase I inhibitor-9TopoisomeraseLeishmaniasisantileishmanialL. donovani promastigotesInhibitorinhibitorinhibit

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