atherogenesis

By Targets:	ADAMTS (1) Chemerin Receptor (1) FLAP (1) Leukotriene Receptor (1) NO Synthase (1) NOD-like Receptor (NLR) (1) Phospholipase (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (7) Endocrinology (1) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114348

N,N'-Diacetyl-L-cystine DiNAC; (Ac-Cys-OH)2	Others	Cardiovascular Disease
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .

HY-P2812

Phospholipase D, Streptomyces chromofuscus PLD	Phospholipase	Neurological Disease Inflammation/Immunology Endocrinology Cancer
Phospholipase D, Streptomyces chromofuscus (PLD) is an enzyme of the phospholipase superfamily, which widely exists in bacteria, yeast, plants, animals and viruses, and is often used in biochemical research. Phospholipase D can catalyze the hydrolysis of phosphodiester bonds in glycerophospholipids to produce phosphatidic acid and soluble choline. Phospholipase D is involved in a variety of disease-related processes, including diabetes, atherogenesis, obesity, tumorigenesis, immune response, and neuroendocrine function .

HY-NP135

Oxidized low density lipoprotein (Human) Human ox-LDL	NO Synthase NOD-like Receptor (NLR)	Metabolic Disease Inflammation/Immunology
Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate NLRP3 inflammasome in macrophages .

HY-14165

Veliflapon BAY X 1005; DG-031	FLAP Leukotriene Receptor	Cardiovascular Disease Inflammation/Immunology
Veliflapon (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor . Veliflapon inhibits the synthesis of the leukotrienes B4 and C4 .

HY-162284

BAY-9835	ADAMTS	Cardiovascular Disease
BAY-9835 is a potent and orally active ADAMTS7 and ADAMTS12 antagonist with IC₅₀s of 6 nM and 30 nM, respectively. BAY-9835 is very selective against a range of off-targets and metalloproteases. BAY-9835 can be used for the atherogenesis research .

HY-P2712

Chemerin-9, mouse Chemerin148–156, mouse	Chemerin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC₅₀ = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC₅₀ = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis .

HY-114348R

N,N'-Diacetyl-L-cystine (Standard)	Others	Cardiovascular Disease
N,N'-Diacetyl-L-cystine (Standard) is the analytical standard of N,N'-Diacetyl-L-cystine. This product is intended for research and analytical applications. N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .

Cat. No.	Product Name	Type

HY-NP135

Oxidized low density lipoprotein (Human) Human ox-LDL	Native Proteins
Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate NLRP3 inflammasome in macrophages .

Oxidized low density lipoprotein (Human)

Human ox-LDL

Native Proteins

Oxidized low density lipoprotein (Human) (Human ox-LDL) is involved in atherogenesis. Oxidized low density lipoprotein (Human) induces endothelial dysfunction via cytoplasmic adapter protein TRAF3IP2. Oxidized low density lipoprotein (Human) can stimulate the activation of endothelial cells and the production of adhesion molecules, and inhibits eNOS activity and NO production. Oxidized low density lipoprotein (Human) can activate NLRP3 inflammasome in macrophages .

Cat. No.	Product Name	Target	Research Area

HY-P2712

Chemerin-9, mouse Chemerin148–156, mouse	Chemerin Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin-9, mouse (Chemerin148-156, mouse) is a C-terminal nonapeptide of chemerin. Chemerin-9, mouse is a ligand for ChemR23 (EC₅₀ = 42 nM). Chemerin-9, mouse reduces basal lipolysis in primary mouse white adipocytes(IC₅₀ = 3.3 nM). Chemerin-9, mouse enhances memory and relieves Aβ1-42-induced memory impairment in AD mice. Chemerin-9, mouse also inhibits atherogenesis .

HY-P1824

C-Reactive Protein (CRP) (201-206)	Peptides	Cardiovascular Disease Inflammation/Immunology
C-Reactive Protein (CRP) 201-206 is the 201-206 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis .

HY-P1836

C-Reactive Protein (CRP) (77-82)	Peptides	Cardiovascular Disease Inflammation/Immunology
C-Reactive Protein (CRP) 77-82 is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis .

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