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chemosensitizers

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (8) Bacterial (1) Deubiquitinase (1) DNA Methyltransferase (3) DNA/RNA Synthesis (1) Endogenous Metabolite (1) HBV (1) iGluR (1) Isotope-Labeled Compounds (3) Keap1-Nrf2 (1) Mitochondrial Metabolism (1) NF-κB (1) P-glycoprotein (6) PARP (1) Sirtuin (2)
By Research Areas:	Cancer (25) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (3) Metabolic Disease (3) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103721

SIRT6-IN-2	Sirtuin	Cancer
SIRT6-IN-2 (Compound 5) is a selective SIRT6 inhibitor (IC₅₀: 34 μM). SIRT6-IN-2 increases acetylation of H3K9 and increases glucose uptake in cultured cells. SIRT6-IN-2 also reduces T cell proliferation. SIRT6-IN-2 has immunosuppressive and chemosensitizing effects .

HY-B0106

Levetiracetam 1 Publications Verification UCB L059	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent .

HY-101453

Ceefourin 1	Others	Cancer
Ceefourin 1 is a potent and highly selective multidrug resistance protein 4 (MRP4) inhibitor. Ceefourin 1 inhibits transport of a broad range of MRP4 substrates, yet is highly selective for MRP4 over other ABC transporters. Ceefourin 1 is a benzothiazol and primarily as a chemosensitizer for high-risk neuroblastoma .

HY-17384

Valspodar 15+ Cited Publications PSC 833	P-glycoprotein	Cancer
Valspodar (PSC 833) is a selective P-glycoprotein inhibitor that has been used as an experimental cancer treatment and chemosensitizer.

HY-136934

Reversin 205 [Boc-Glu(Obzl)]2-Lys-Ome	P-glycoprotein	Cancer
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

HY-157448

CBR1-IN-6	Apoptosis	Cancer
CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities .

HY-N2104

Daurinoline	Others	Cancer
Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research .

HY-123401

DDRI-18	DNA/RNA Synthesis	Cancer
DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent .

HY-14688

CEP-8983	PARP	Cancer
CEP-8983 is a PARP-1 and PARP-2 inhibitor (IC₅₀: 20 and 6 nM). CEP-8983 is an effective chemosensitizing agent, and can sensitize chemotherapy-resistant cell lines and subcutaneous xenografts to Temozolomide (HY-17364) and Camptothecin (HY-16560) .

HY-120432

CaMdr1p-IN-1	Others	Infection
CaMdr1p-IN-1 (Compound A) is an inhibitor for the major facilitator superfamily transporter CaMdr1p. CaMdr1p-IN-1 exhibits chemosensitizing efficacy. CaMdr1p-IN-1 synergizes with Fluconazole (HY-B0101), that inhibits CaMdr1p overexpressing Candida albicans with MIC of 10 μM .

HY-13574A

Biricodar 1 Publications Verification VX-710	P-glycoprotein	Cancer
Biricodar (VX-710) is a modulator of P-glycoprotein and MRP-1; shows effective chemosensitizing activity in multidrug resistant cells.

HY-121196

Achillin	Others	Others
Achillin is a chemosensitizing compound that can enhance the cytotoxicity of paclitaxel to hepatocellular carcinoma cells, induce cell cycle arrest and apoptosis, and may also reverse multidrug resistance by regulating P-gp levels.

HY-135336

(R)-Verapamil hydrochloride (R)-(+)-Verapamil hydrochloride	P-glycoprotein Apoptosis	Cancer
(R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents .

HY-114410

CCI-006	Mitochondrial Metabolism	Cancer
CCI-006 is a selective inhibitor and chemosensitizer of MLL-rearranged leukemia cells, by inhibits mitochondrial respiration resulting in insurmountable mitochondrial depolarization and a pro-apoptotic unfolded protein response (UPR) in a subset of MLL-r leukemia cells .

HY-W014118

α-Hexylcinnamaldehyde	Others	Cancer
α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-145967

FT709 1 Publications Verification	Deubiquitinase	Cancer
FT709 is a potent and selective USP9X inhibitor, an IC₅₀ of 82 nM. USP9X has been linked with centrosome function, chromosome alignment during mitosis, EGF receptor degradation, chemo-sensitization, and circadian rhythms .

HY-135336S

(R)-Verapamil-d7 hydrochloride (R)-(+)-Verapamil-d₇ hydrochloride	Isotope-Labeled Compounds P-glycoprotein Apoptosis	Cancer
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-13574

Biricodar dicitrate VX 710-3	P-glycoprotein	Cancer
Biricodar dicitrate (VX 710-3) is the dicitrate salt form of Biricodar (HY-13574A). Biricodar dicitrate is an inhibitor for P-glycoprotein and multidrug resistance-associated protein 1 (MRP-1), which increases the accumulation of chemotherapy drugs within cancer cells and shows effective chemosensitizing activity in multidrug resistant cells .

HY-B0106S

Levetiracetam-d6 UCB L059-d₆	Isotope-Labeled Compounds DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-B0106S1

Levetiracetam-d3 UCB L059-d₃	DNA Methyltransferase	Neurological Disease Cancer
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-N0368S1

Linalool-13C3	Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds	Cancer
Linalool- ¹³C₃ is ¹³C labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-W014118R

α-Hexylcinnamaldehyde (Standard)	Others	Cancer
α-Hexylcinnamaldehyde (Standard) is the analytical standard of α-Hexylcinnamaldehyde. This product is intended for research and analytical applications. α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-111193

Declopramide 3-Chloroprocainamide	NF-κB Apoptosis	Cancer
Declopramide (3-Chloroprocainamide) is an orally active antitumor agent, which inhibits proliferation of cancer cells HL60 and K562, and inhibits tumor growth of human brain astrocytoma (T24) in mouse model. Declopramide induces apoptosis, inhibits NF-κB through inhibition of IκBα degradation. Declopramide serves also as chemosensitizer in research .

HY-N0669

Stevioside 2 Publications Verification	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-N0669R

Stevioside (Standard)	Apoptosis	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Stevioside (Standard) is the analytical standard of Stevioside. This product is intended for research and analytical applications. Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-107454

OSS_128167 15+ Cited Publications	Sirtuin HBV	Infection Metabolic Disease Inflammation/Immunology Cancer
OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC₅₀s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects .

HY-19543

Brusatol Maximum Cited Publications 27 Publications Verification NSC 172924	Keap1-Nrf2 Apoptosis	Cancer
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

Cat. No.	Product Name	Target	Research Area

HY-136934

Reversin 205 [Boc-Glu(Obzl)]2-Lys-Ome	P-glycoprotein	Cancer
Reversin 205 ([Boc-Glu(Obzl)]2-Lys-Ome) is a P-glycoprotein (ABCB1) inhibitor. Reversin 205 is a peptide chemosensitizer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W014118

α-Hexylcinnamaldehyde	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Others
α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-N0669

Stevioside 2 Publications Verification	Structural Classification Trifolium hybridum L. Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Compositae Disease Research Fields Sweeteners Cancer Food Research	Apoptosis
Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

HY-19543

Brusatol 25+ Cited Publications NSC 172924	Structural Classification Simaroubaceae Classification of Application Fields Terpenoids Source classification Diterpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Cancer	Keap1-Nrf2 Apoptosis
Brusatol (NSC 172924) is a unique inhibitor of the Nrf2 pathway that sensitizes a broad spectrum of cancer cells to Cisplatin and other chemotherapeutic agents. Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism. Brusatol can be developed into an adjuvant chemotherapeutic agent . Brusatol increases cellular apoptosis .

HY-N2104

Daurinoline	Alkaloids Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Menispermaceae Disease Research Fields Menispermum dauricum Alkaloid Dimers Cancer	Others
Daurinoline is an alkaloid that can be isolated from the roots of Menispermum dauricum. Daurinoline may be a potential anti-tumor agent or chemosensitizer for chemo-resistant NSCLC research .

HY-121196

Achillin	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Compositae Achillea millefolium L.	Others
Achillin is a chemosensitizing compound that can enhance the cytotoxicity of paclitaxel to hepatocellular carcinoma cells, induce cell cycle arrest and apoptosis, and may also reverse multidrug resistance by regulating P-gp levels.

HY-W014118R

α-Hexylcinnamaldehyde (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Others
α-Hexylcinnamaldehyde (Standard) is the analytical standard of α-Hexylcinnamaldehyde. This product is intended for research and analytical applications. α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

HY-N0669R

Stevioside (Standard)	Structural Classification Trifolium hybridum L. Terpenoids Source classification Diterpenoids Plants Compositae	Apoptosis
Stevioside (Standard) is the analytical standard of Stevioside. This product is intended for research and analytical applications. Stevioside is an orally active sweetener that can be isolated from Stevia rebaudiana, with antihypertensive, antihyperglycemic, antioxidant, anti-inflammatory and anti-tumor activities .

Cat. No.	Product Name	Chemical Structure

HY-135336S

(R)-Verapamil-d7 hydrochloride
(R)-Verapamil-d₇ (hydrochloride) is a deuterium labeled (R)-Verapamil hydrochloride. (R)-Verapamil hydrochloride ((R)-(+)-Verapamil hydrochloride) is a P-Glycoprotein inhibitor. (R)-Verapamil hydrochloride blocks MRP1 mediated transport, resulting in chemosensitization of MRP1-overexpressing cells to anticancer agents[1][2].

HY-B0106S

Levetiracetam-d6
Levetiracetam-d₆ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-B0106S1

Levetiracetam-d3
Levetiracetam-d₃ is the deuterium labeled Levetiracetam. Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT, thus increasing Temozolomide effectiveness. A chemosensitizer agent[1][2].

HY-N0368S1

Linalool-13C3
Linalool- ¹³C₃ is ¹³C labeled α-Hexylcinnamaldehyde (HY-W014118). α-Hexylcinnamaldehyde, a compound derived from Cinnamaldehyde. α-Hexylcinnamaldehyde has the potential antimutagenic and chemosensitizing properties. α-Hexylcinnamaldehyde is widely used as an ingredient in many personal care, and as an additive in food and the pharmaceutical industry .

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chemosensitizers

Inhibitors & Agonists

Peptides

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Isotope-Labeled Compounds

Natural
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