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Results for "

cholecystokinin-B

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholecystokinin Receptor (13)
By Research Areas:	Cancer (4) Endocrinology (4) Inflammation/Immunology (1) Metabolic Disease (6) Neurological Disease (2)

13

Inhibitors & Agonists

2

Peptides

Targets Recommended: Cholecystokinin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

[Leu15]-Gastrin I (human)	Cholecystokinin Receptor	Cancer
[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer .

(Rac)-Sograzepide (Rac)-Netazepide; (Rac)-YF 476; (Rac)-YM-220	Cholecystokinin Receptor	Metabolic Disease
(Rac)-Sograzepide is an antagonist of cholecystokinin B (CCK-B) receptor, and has the potential of reducing the secretion of gastric acid.

Pentagastrin 1 Publications Verification ICI-50123	Cholecystokinin Receptor	Endocrinology Cancer
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury . .

L-740093	Cholecystokinin Receptor	Metabolic Disease
L-740093 is a potent cholecystokinin-B receptor antagonist. L-740093 has excellent central nervous system (CNS) penetration .

Spiroglumide CR-2194	Cholecystokinin Receptor	Metabolic Disease
Spiroglumide (CR-2194) is a selective cholecystokinin B (CCKB) receptor antagonist .

L 368935	Cholecystokinin Receptor	Neurological Disease
L 368935 is a cholecystokinin B receptor (CCKB receptor) antagonist. L 368935 is a brain-penetrant and centrally active compound .

PD 140376	Cholecystokinin Receptor	Metabolic Disease
PD 140376 is a potent antagonist for the cholecystokininB/gastrin receptor, with K_i values of 0.18 nM and 0.21 nM in guinea-pig cortex and gastric gland membranes, respectively .

PD-149164	Cholecystokinin Receptor	Metabolic Disease Endocrinology
PD-149164 is a potent agonist of cholecystokinin B (CCK-B) receptor, with IC₅₀ values of 0.083 nM and 75 nM in binding assay to CCK-B and CCK-A .

RP73870	Cholecystokinin Receptor	Inflammation/Immunology
RP73870 is an orally active *gastrin/cholecystokinin-B* receptor antagonist. RP73870 inhibits basal gastric acid secretion in the rat. RP73870 has potent anti-ulcer activity .

Pentagastrin meglumine ICI-50123 meglumine	Cholecystokinin Receptor	Endocrinology Cancer
Pentagastrin (ICI-50123) meglumine is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin meglumine enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury . .

PD-135666	Cholecystokinin Receptor	Neurological Disease
PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models .

AG-041R	Cholecystokinin Receptor	Endocrinology Cancer
AG-041R is a potent and selective CCK2 Receptor/Gastrin antagonist. AG-041R inhibits gastrin-evoked secretion of pancreastatin with an IC₅₀ of 2.2 nM. AG-041R inhibits cell growth of Mastomys ECL carcinoid tumor cells .

L-736380	Cholecystokinin Receptor	Metabolic Disease
L-736380 is a high affinity *CCK-B (cholecystokinin B* receptor)** receptor antagonist, with IC₅₀ values of 0.054 nM and 400 nM for CCK-B and CCK-A, respectively. L-736380 dose-dependently inhibits gastric acid secretion in anesthetized rats (ID₅₀, 0.064 mg/kg) and ex vivo binding of [125I]CCK-8S in BKTO mice brain membranes (ED₅₀, 1.7 mg/kg) .

Cat. No.	Product Name	Target	Research Area

[Leu15]-Gastrin I (human)	Cholecystokinin Receptor	Cancer
[Leu15]-Gastrin I (human) is a Gastrin I, human (HY-P1097) peptide hormone derivative, which is trophic for normal gastrointestinal epithelium. Gastrin stimulates growth of gastric adenocarcinoma (gastric cancer) through G-protein-coupled receptor called the cholecystokinin (CCK) or cholecystokinin-B receptors (CCK-BR) that are overexpressed in this malignancy. [Leu15]-Gastrin I (human) is promising for research of gastric cancer .

Pentagastrin 1 Publications Verification ICI-50123	Cholecystokinin Receptor	Endocrinology Cancer
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCK_B) receptor antagonists with IC₅₀ values of 11 nM and 1100 nM for CCK_B and CCK_A, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury . .

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