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Results for "

chromosome segregation

" in MedChemExpress (MCE) Product Catalog:

4

Inhibitors & Agonists

1

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122236
    UMK57

    		Others Others
    UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis .
    UMK57
  • HY-138084
    SIC5-6

    		Separase Cancer
    SIC5-6 is a potent Separase inhibitor. Separase, a large cysteine protease, involves in chromosome segregation during mitosis and meiosis, DNA damage repair, centrosome disengagement and duplication, spindle stabilization and elongation. Separase is highly overexpressed in many solid cancers, serves as an attractive chemotherapeutic target .
    SIC5-6
  • HY-N13008
    4-Hydroxy-sterigmatocystin

    		Bacterial Infection
    4-Hydroxy-sterigmatocystin (compd 1) is a ParB inhibitor with antibacterial activity. 4-Hydroxy-sterigmatocystin can bind to purified ParB in a ParS-modulated manner and inhibits its ParS-dependent CTPase activity .
    4-Hydroxy-sterigmatocystin
  • HY-158038
    AurkA allosteric-IN-1

    		Aurora Kinase Cancer
    AurkA allosteric-IN-1 (compound 6h) is an Aurora A (AurkA) inhibitor (IC50: 6.50 μM) that inhibits the catalytic activity and non-catalytic functions of Aurora A. Aurora A regulates the assembly of the bipolar mitotic spindle and the fidelity of chromosome segregation during mitosis and has non-catalytic functions. AurkA allosteric-IN-1 blocks the interaction of AurkA with the activator TPX2 by binding to the Y pocket of AurkA .
    AurkA allosteric-IN-1

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