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Results for "

cortical histamine

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101321A
    Immepip dihydrobromide

    		Itk Neurological Disease
    Immepip dihydrobromide is a H3 agonist. Immepip dihydrobromide can reduce cortical histamine release. Immepip dihydrobromide can be used for the research of neurological diseases .
    Immepip dihydrobromide
  • HY-101321
    Immepip

    		Histamine Receptor Neurological Disease
    Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases .
    Immepip
  • HY-113802
    VUF 8328

    		Histamine Receptor Neurological Disease
    VUF 8328 is a potent histamine H(3) receptor agonist. VUF 8328 inhibits the electrically-evoked [ 3H]-no-radrenaline release from rat cortical slices. VUF 8328 is promising for research of central nervous system disorders .
    VUF 8328
  • HY-12193
    A-349821

    		Histamine Receptor Others
    A-349821 is a histamine H3 receptor antagonist characterized as a radioligand ([3H]-A-349821) for in vivo receptor occupancy assessment. In rats, [3H]-A-349821 penetrated the brain, showing higher levels in the cortex compared to the cerebellum, indicating selective H3 receptor binding. Its cortical occupancy was saturable, correlating with in vitro binding data. Inhibition studies with ABT-239 and other H3 antagonists showed dose-dependent reductions in receptor occupancy, matching blood levels associated with cognitive efficacy in preclinical models. [3H]-A-349821 thus serves as a valid tracer for H3 receptor occupancy, aiding in the development and clinical interpretation of H3 receptor antagonists .
    A-349821

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